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The Novel Glutamine Antagonist Prodrug JHU395 Has Antitumor Activity in Malignant Peripheral Nerve Sheath Tumor.
Lemberg KM, Zhao L, Wu Y, Veeravalli V, Alt J, Aguilar JMH, Dash RP, Lam J, Tenora L, Rodriguez C, Nedelcovych MT, Brayton C, Majer P, Blakeley JO, Rais R, Slusher BS. Lemberg KM, et al. Among authors: zhao l. Mol Cancer Ther. 2020 Feb;19(2):397-408. doi: 10.1158/1535-7163.MCT-19-0319. Epub 2019 Oct 8. Mol Cancer Ther. 2020. PMID: 31594823 Free PMC article.
Combination therapy with BPTES nanoparticles and metformin targets the metabolic heterogeneity of pancreatic cancer.
Elgogary A, Xu Q, Poore B, Alt J, Zimmermann SC, Zhao L, Fu J, Chen B, Xia S, Liu Y, Neisser M, Nguyen C, Lee R, Park JK, Reyes J, Hartung T, Rojas C, Rais R, Tsukamoto T, Semenza GL, Hanes J, Slusher BS, Le A. Elgogary A, et al. Among authors: zhao l. Proc Natl Acad Sci U S A. 2016 Sep 6;113(36):E5328-36. doi: 10.1073/pnas.1611406113. Epub 2016 Aug 24. Proc Natl Acad Sci U S A. 2016. PMID: 27559084 Free PMC article.
Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion.
Leone RD, Zhao L, Englert JM, Sun IM, Oh MH, Sun IH, Arwood ML, Bettencourt IA, Patel CH, Wen J, Tam A, Blosser RL, Prchalova E, Alt J, Rais R, Slusher BS, Powell JD. Leone RD, et al. Among authors: zhao l. Science. 2019 Nov 22;366(6468):1013-1021. doi: 10.1126/science.aav2588. Epub 2019 Nov 7. Science. 2019. PMID: 31699883 Free PMC article.
Discovery of DRP-104, a tumor-targeted metabolic inhibitor prodrug.
Rais R, Lemberg KM, Tenora L, Arwood ML, Pal A, Alt J, Wu Y, Lam J, Aguilar JMH, Zhao L, Peters DE, Tallon C, Pandey R, Thomas AG, Dash RP, Seiwert T, Majer P, Leone RD, Powell JD, Slusher BS. Rais R, et al. Among authors: zhao l. Sci Adv. 2022 Nov 18;8(46):eabq5925. doi: 10.1126/sciadv.abq5925. Epub 2022 Nov 16. Sci Adv. 2022. PMID: 36383674 Free PMC article.
Glutamine metabolism inhibition has dual immunomodulatory and antibacterial activities against Mycobacterium tuberculosis.
Parveen S, Shen J, Lun S, Zhao L, Koleske B, Leone RD, Rais R, Powell JD, Murphy JR, Slusher BS, Bishai WR. Parveen S, et al. Among authors: zhao l. bioRxiv [Preprint]. 2023 Feb 23:2023.02.23.529704. doi: 10.1101/2023.02.23.529704. bioRxiv. 2023. Update in: Nat Commun. 2023 Nov 16;14(1):7427. doi: 10.1038/s41467-023-43304-0 PMID: 36865287 Free PMC article. Updated. Preprint.
Pro-905, a Novel Purine Antimetabolite, Combines with Glutamine Amidotransferase Inhibition to Suppress Growth of Malignant Peripheral Nerve Sheath Tumor.
Lemberg KM, Ali ES, Krecmerova M, Aguilar JMH, Alt J, Peters DE, Zhao L, Wu Y, Nuha N, Asara JM, Staedtke V, Pratilas CA, Majer P, Rais R, Ben-Sahra I, Slusher BS. Lemberg KM, et al. Among authors: zhao l. Mol Cancer Ther. 2023 Dec 1;22(12):1390-1403. doi: 10.1158/1535-7163.MCT-23-0258. Mol Cancer Ther. 2023. PMID: 37616542 Free PMC article.
Metabolic Reprogramming of Tumor-Associated Macrophages Using Glutamine Antagonist JHU083 Drives Tumor Immunity in Myeloid-Rich Prostate and Bladder Cancers.
Praharaj M, Shen F, Lee AJ, Zhao L, Nirschl TR, Theodros D, Singh AK, Wang X, Adusei KM, Lombardo KA, Williams RA, Sena LA, Thompson EA, Tam A, Yegnasubramanian S, Pearce EJ, Leone RD, Alt J, Rais R, Slusher BS, Pardoll DM, Powell JD, Zarif JC. Praharaj M, et al. Among authors: zhao l. Cancer Immunol Res. 2024 Jul 2;12(7):854-875. doi: 10.1158/2326-6066.CIR-23-1105. Cancer Immunol Res. 2024. PMID: 38701369 Free PMC article.
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