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VacA generates a protective intracellular reservoir for Helicobacter pylori that is eliminated by activation of the lysosomal calcium channel TRPML1.
Capurro MI, Greenfield LK, Prashar A, Xia S, Abdullah M, Wong H, Zhong XZ, Bertaux-Skeirik N, Chakrabarti J, Siddiqui I, O'Brien C, Dong X, Robinson L, Peek RM Jr, Philpott DJ, Zavros Y, Helmrath M, Jones NL. Capurro MI, et al. Nat Microbiol. 2019 Aug;4(8):1411-1423. doi: 10.1038/s41564-019-0441-6. Epub 2019 May 20. Nat Microbiol. 2019. PMID: 31110360 Free PMC article.
Vitamin D deficiency enhances expression of autophagy-regulating miR-142-3p in mouse and "involved" IBD patient intestinal tissues.
McGillis L, Bronte-Tinkew DM, Dang F, Capurro M, Prashar A, Ricciuto A, Greenfield L, Lozano-Ruf A, Siddiqui I, Hsieh A, Church P, Walters T, Roth DE, Griffiths A, Philpott D, Jones NL. McGillis L, et al. Am J Physiol Gastrointest Liver Physiol. 2021 Aug 1;321(2):G171-G184. doi: 10.1152/ajpgi.00398.2020. Epub 2021 Jun 23. Am J Physiol Gastrointest Liver Physiol. 2021. PMID: 34159811 Free article.
The chemorepellent, SLIT2, bolsters innate immunity against Staphylococcus aureus.
Bhosle VK, Sun C, Patel S, Ho TWW, Westman J, Ammendolia DA, Langari FM, Fine N, Toepfner N, Li Z, Sharma M, Glogauer J, Capurro MI, Jones NL, Maynes JT, Lee WL, Glogauer M, Grinstein S, Robinson LA. Bhosle VK, et al. Among authors: capurro mi. Elife. 2023 Sep 29;12:e87392. doi: 10.7554/eLife.87392. Elife. 2023. PMID: 37773612 Free PMC article.
Lysosomes drive the piecemeal removal of mitochondrial inner membrane.
Prashar A, Bussi C, Fearns A, Capurro MI, Gao X, Sesaki H, Gutierrez MG, Jones NL. Prashar A, et al. Among authors: capurro mi. Nature. 2024 Aug;632(8027):1110-1117. doi: 10.1038/s41586-024-07835-w. Epub 2024 Aug 21. Nature. 2024. PMID: 39169179 Free PMC article.
16 results