Swamidass SJ - Search Results

1

Comprehensive kinetic and modeling analyses revealed CYP2C9 and 3A4 determine terbinafine metabolic clearance and bioactivation.

Barnette DA, Davis MA, Flynn N, Pidugu AS, Swamidass SJ, Miller GP. Barnette DA, et al. Among authors: swamidass sj. Biochem Pharmacol. 2019 Dec;170:113661. doi: 10.1016/j.bcp.2019.113661. Epub 2019 Oct 9. Biochem Pharmacol. 2019. PMID: 31605674 Free PMC article.

2

Site of reactivity models predict molecular reactivity of diverse chemicals with glutathione.

Hughes TB, Miller GP, Swamidass SJ. Hughes TB, et al. Among authors: swamidass sj. Chem Res Toxicol. 2015 Apr 20;28(4):797-809. doi: 10.1021/acs.chemrestox.5b00017. Epub 2015 Mar 16. Chem Res Toxicol. 2015. PMID: 25742281 Free PMC article.

3

Modeling Epoxidation of Drug-like Molecules with a Deep Machine Learning Network.

Hughes TB, Miller GP, Swamidass SJ. Hughes TB, et al. Among authors: swamidass sj. ACS Cent Sci. 2015 Jul 22;1(4):168-80. doi: 10.1021/acscentsci.5b00131. Epub 2015 Jun 9. ACS Cent Sci. 2015. PMID: 27162970 Free PMC article.

4

Modeling Reactivity to Biological Macromolecules with a Deep Multitask Network.

Hughes TB, Dang NL, Miller GP, Swamidass SJ. Hughes TB, et al. Among authors: swamidass sj. ACS Cent Sci. 2016 Aug 24;2(8):529-37. doi: 10.1021/acscentsci.6b00162. Epub 2016 Jul 29. ACS Cent Sci. 2016. PMID: 27610414 Free PMC article.

5

Computational Approach to Structural Alerts: Furans, Phenols, Nitroaromatics, and Thiophenes.

Dang NL, Hughes TB, Miller GP, Swamidass SJ. Dang NL, et al. Among authors: swamidass sj. Chem Res Toxicol. 2017 Apr 17;30(4):1046-1059. doi: 10.1021/acs.chemrestox.6b00336. Epub 2017 Mar 14. Chem Res Toxicol. 2017. PMID: 28256829 Free PMC article.

6

Computationally Assessing the Bioactivation of Drugs by N-Dealkylation.

Dang NL, Hughes TB, Miller GP, Swamidass SJ. Dang NL, et al. Among authors: swamidass sj. Chem Res Toxicol. 2018 Feb 19;31(2):68-80. doi: 10.1021/acs.chemrestox.7b00191. Epub 2018 Feb 6. Chem Res Toxicol. 2018. PMID: 29355304 Free PMC article.

7

Lamisil (terbinafine) toxicity: Determining pathways to bioactivation through computational and experimental approaches.

Barnette DA, Davis MA, Dang NL, Pidugu AS, Hughes T, Swamidass SJ, Boysen G, Miller GP. Barnette DA, et al. Among authors: swamidass sj. Biochem Pharmacol. 2018 Oct;156:10-21. doi: 10.1016/j.bcp.2018.07.043. Epub 2018 Aug 2. Biochem Pharmacol. 2018. PMID: 30076845 Free PMC article.

8

CYP2C19 and 3A4 Dominate Metabolic Clearance and Bioactivation of Terbinafine Based on Computational and Experimental Approaches.

Davis MA, Barnette DA, Flynn NR, Pidugu AS, Swamidass SJ, Boysen G, Miller GP. Davis MA, et al. Among authors: swamidass sj. Chem Res Toxicol. 2019 Jun 17;32(6):1151-1164. doi: 10.1021/acs.chemrestox.9b00006. Epub 2019 Apr 10. Chem Res Toxicol. 2019. PMID: 30925039 Free PMC article.

9

A Time-Embedding Network Models the Ontogeny of 23 Hepatic Drug Metabolizing Enzymes.

Matlock MK, Tambe A, Elliott-Higgins J, Hines RN, Miller GP, Swamidass SJ. Matlock MK, et al. Among authors: swamidass sj. Chem Res Toxicol. 2019 Aug 19;32(8):1707-1721. doi: 10.1021/acs.chemrestox.9b00223. Epub 2019 Jul 29. Chem Res Toxicol. 2019. PMID: 31304741 Free PMC article.

10

Dual mechanisms suppress meloxicam bioactivation relative to sudoxicam.

Barnette DA, Schleiff MA, Osborn LR, Flynn N, Matlock M, Swamidass SJ, Miller GP. Barnette DA, et al. Among authors: swamidass sj. Toxicology. 2020 Jul;440:152478. doi: 10.1016/j.tox.2020.152478. Epub 2020 May 11. Toxicology. 2020. PMID: 32437779 Free PMC article.

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