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Screening, large-scale production and structure-based classification of cystine-dense peptides.
Correnti CE, Gewe MM, Mehlin C, Bandaranayake AD, Johnsen WA, Rupert PB, Brusniak MY, Clarke M, Burke SE, De Van Der Schueren W, Pilat K, Turnbaugh SM, May D, Watson A, Chan MK, Bahl CD, Olson JM, Strong RK. Correnti CE, et al. Among authors: olson jm. Nat Struct Mol Biol. 2018 Mar;25(3):270-278. doi: 10.1038/s41594-018-0033-9. Epub 2018 Feb 26. Nat Struct Mol Biol. 2018. PMID: 29483648 Free PMC article.
Miniproteins as a Powerful Modality in Drug Development.
Crook ZR, Nairn NW, Olson JM. Crook ZR, et al. Among authors: olson jm. Trends Biochem Sci. 2020 Apr;45(4):332-346. doi: 10.1016/j.tibs.2019.12.008. Epub 2020 Jan 31. Trends Biochem Sci. 2020. PMID: 32014389 Free PMC article. Review.
A potent peptide-steroid conjugate accumulates in cartilage and reverses arthritis without evidence of systemic corticosteroid exposure.
Cook Sangar ML, Girard EJ, Hopping G, Yin C, Pakiam F, Brusniak MY, Nguyen E, Ruff R, Gewe MM, Byrnes-Blake K, Nairn NW, Miller DM, Mehlin C, Strand AD, Mhyre AJ, Correnti CE, Strong RK, Simon JA, Olson JM. Cook Sangar ML, et al. Among authors: olson jm. Sci Transl Med. 2020 Mar 4;12(533):eaay1041. doi: 10.1126/scitranslmed.aay1041. Sci Transl Med. 2020. PMID: 32132215
A TfR-Binding Cystine-Dense Peptide Promotes Blood-Brain Barrier Penetration of Bioactive Molecules.
Crook ZR, Girard E, Sevilla GP, Merrill M, Friend D, Rupert PB, Pakiam F, Nguyen E, Yin C, Ruff RO, Hopping G, Strand AD, Finton KAK, Coxon M, Mhyre AJ, Strong RK, Olson JM. Crook ZR, et al. Among authors: olson jm. J Mol Biol. 2020 Jun 26;432(14):3989-4009. doi: 10.1016/j.jmb.2020.04.002. Epub 2020 Apr 15. J Mol Biol. 2020. PMID: 32304700 Free PMC article.
Optimal therapeutic targeting by HDAC inhibition in biopsy-derived treatment-naïve diffuse midline glioma models.
Vitanza NA, Biery MC, Myers C, Ferguson E, Zheng Y, Girard EJ, Przystal JM, Park G, Noll A, Pakiam F, Winter CA, Morris SM, Sarthy J, Cole BL, Leary SES, Crane C, Lieberman NAP, Mueller S, Nazarian J, Gottardo R, Brusniak MY, Mhyre AJ, Olson JM. Vitanza NA, et al. Among authors: olson jm. Neuro Oncol. 2021 Mar 25;23(3):376-386. doi: 10.1093/neuonc/noaa249. Neuro Oncol. 2021. PMID: 33130903 Free PMC article.
430 results