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Discovery of 5-(4-hydroxyphenyl)-3-oxo-pentanoic acid [2-(5-methoxy-1H-indol-3-yl)-ethyl]-amide as a neuroprotectant for Alzheimer's disease by hybridization of curcumin and melatonin.
Chojnacki JE, Liu K, Yan X, Toldo S, Selden T, Estrada M, Rodríguez-Franco MI, Halquist MS, Ye D, Zhang S. Chojnacki JE, et al. Among authors: zhang s. ACS Chem Neurosci. 2014 Aug 20;5(8):690-9. doi: 10.1021/cn500081s. Epub 2014 May 22. ACS Chem Neurosci. 2014. PMID: 24825313 Free PMC article.
Pharmacologic Inhibition of the NLRP3 Inflammasome Preserves Cardiac Function After Ischemic and Nonischemic Injury in the Mouse.
Marchetti C, Toldo S, Chojnacki J, Mezzaroma E, Liu K, Salloum FN, Nordio A, Carbone S, Mauro AG, Das A, Zalavadia AA, Halquist MS, Federici M, Van Tassell BW, Zhang S, Abbate A. Marchetti C, et al. Among authors: zhang s. J Cardiovasc Pharmacol. 2015 Jul;66(1):1-8. doi: 10.1097/FJC.0000000000000247. J Cardiovasc Pharmacol. 2015. PMID: 25915511 Free PMC article.
Development and Characterization of a Hydroxyl-Sulfonamide Analogue, 5-Chloro-N-[2-(4-hydroxysulfamoyl-phenyl)-ethyl]-2-methoxy-benzamide, as a Novel NLRP3 Inflammasome Inhibitor for Potential Treatment of Multiple Sclerosis.
Guo C, Fulp JW, Jiang Y, Li X, Chojnacki JE, Wu J, Wang XY, Zhang S. Guo C, et al. Among authors: zhang s. ACS Chem Neurosci. 2017 Oct 18;8(10):2194-2201. doi: 10.1021/acschemneuro.7b00124. Epub 2017 Jul 13. ACS Chem Neurosci. 2017. PMID: 28653829 Free PMC article.
Insights into the Impact of a Membrane-Anchoring Moiety on the Biological Activities of Bivalent Compounds As Potential Neuroprotectants for Alzheimer's Disease.
He L, Jiang Y, Liu K, Gomez-Murcia V, Ma X, Torrecillas A, Chen Q, Zhu X, Lesnefsky E, Gomez-Fernandez JC, Xu B, Zhang S. He L, et al. Among authors: zhang s. J Med Chem. 2018 Feb 8;61(3):777-790. doi: 10.1021/acs.jmedchem.7b01284. Epub 2018 Jan 5. J Med Chem. 2018. PMID: 29271648 Free PMC article.
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