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De novo design of potent and selective mimics of IL-2 and IL-15.
Silva DA, Yu S, Ulge UY, Spangler JB, Jude KM, Labão-Almeida C, Ali LR, Quijano-Rubio A, Ruterbusch M, Leung I, Biary T, Crowley SJ, Marcos E, Walkey CD, Weitzner BD, Pardo-Avila F, Castellanos J, Carter L, Stewart L, Riddell SR, Pepper M, Bernardes GJL, Dougan M, Garcia KC, Baker D. Silva DA, et al. Among authors: spangler jb. Nature. 2019 Jan;565(7738):186-191. doi: 10.1038/s41586-018-0830-7. Epub 2019 Jan 9. Nature. 2019. PMID: 30626941 Free PMC article.
Targeting cancer metastasis with antibody therapeutics.
Yang H, Kuo YH, Smith ZI, Spangler J. Yang H, et al. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2021 Jul;13(4):e1698. doi: 10.1002/wnan.1698. Epub 2021 Jan 18. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2021. PMID: 33463090 Review.
Pharmacodynamic measures within tumors expose differential activity of PD(L)-1 antibody therapeutics.
Kumar D, Mishra A, Lisok A, Kureshi R, Shelake S, Plyku D, Sen R, Doucet M, De Silva RA, Mease RC, Forde PM, Jaffee EM, Desai P, Ganguly S, Gabrielson E, Vaidya D, Spangler JB, Nimmagadda S. Kumar D, et al. Among authors: spangler jb. Proc Natl Acad Sci U S A. 2021 Sep 14;118(37):e2107982118. doi: 10.1073/pnas.2107982118. Proc Natl Acad Sci U S A. 2021. PMID: 34508005 Free PMC article.
A split, conditionally active mimetic of IL-2 reduces the toxicity of systemic cytokine therapy.
Quijano-Rubio A, Bhuiyan AM, Yang H, Leung I, Bello E, Ali LR, Zhangxu K, Perkins J, Chun JH, Wang W, Lajoie MJ, Ravichandran R, Kuo YH, Dougan SK, Riddell SR, Spangler JB, Dougan M, Silva DA, Baker D. Quijano-Rubio A, et al. Among authors: spangler jb. Nat Biotechnol. 2023 Apr;41(4):532-540. doi: 10.1038/s41587-022-01510-z. Epub 2022 Oct 31. Nat Biotechnol. 2023. PMID: 36316485 Free PMC article.
Design of cell-type-specific hyperstable IL-4 mimetics via modular de novo scaffolds.
Yang H, Ulge UY, Quijano-Rubio A, Bernstein ZJ, Maestas DR, Chun JH, Wang W, Lin JX, Jude KM, Singh S, Orcutt-Jahns BT, Li P, Mou J, Chung L, Kuo YH, Ali YH, Meyer AS, Grayson WL, Heller NM, Garcia KC, Leonard WJ, Silva DA, Elisseeff JH, Baker D, Spangler JB. Yang H, et al. Among authors: spangler jb. Nat Chem Biol. 2023 Sep;19(9):1127-1137. doi: 10.1038/s41589-023-01313-6. Epub 2023 Apr 6. Nat Chem Biol. 2023. PMID: 37024727 Free PMC article.
75 results