Yang H - Search Results

1

Structural Basis for Signaling Through Shared Common γ Chain Cytokines.

Yang H, Kureshi R, Spangler JB. Yang H, et al. Adv Exp Med Biol. 2019;1172:1-19. doi: 10.1007/978-981-13-9367-9_1. Adv Exp Med Biol. 2019. PMID: 31628649 Review.

2

Targeting cancer metastasis with antibody therapeutics.

Yang H, Kuo YH, Smith ZI, Spangler J. Yang H, et al. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2021 Jul;13(4):e1698. doi: 10.1002/wnan.1698. Epub 2021 Jan 18. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2021. PMID: 33463090 Review.

3

Engineered bispecific antibodies targeting the interleukin-6 and -8 receptors potently inhibit cancer cell migration and tumor metastasis.

Yang H, Karl MN, Wang W, Starich B, Tan H, Kiemen A, Pucsek AB, Kuo YH, Russo GC, Pan T, Jaffee EM, Fertig EJ, Wirtz D, Spangler JB. Yang H, et al. Mol Ther. 2022 Nov 2;30(11):3430-3449. doi: 10.1016/j.ymthe.2022.07.008. Epub 2022 Jul 16. Mol Ther. 2022. PMID: 35841152 Free PMC article.

4

Poly(Beta-Amino Ester)s as High-Yield Transfection Reagents for Recombinant Protein Production.

Luly KM, Yang H, Lee SJ, Wang W, Ludwig SD, Tarbox HE, Wilson DR, Green JJ, Spangler JB. Luly KM, et al. Among authors: yang h. Int J Nanomedicine. 2022 Sep 23;17:4469-4479. doi: 10.2147/IJN.S377371. eCollection 2022. Int J Nanomedicine. 2022. PMID: 36176585 Free PMC article.

5

A split, conditionally active mimetic of IL-2 reduces the toxicity of systemic cytokine therapy.

Quijano-Rubio A, Bhuiyan AM, Yang H, Leung I, Bello E, Ali LR, Zhangxu K, Perkins J, Chun JH, Wang W, Lajoie MJ, Ravichandran R, Kuo YH, Dougan SK, Riddell SR, Spangler JB, Dougan M, Silva DA, Baker D. Quijano-Rubio A, et al. Among authors: yang h. Nat Biotechnol. 2023 Apr;41(4):532-540. doi: 10.1038/s41587-022-01510-z. Epub 2022 Oct 31. Nat Biotechnol. 2023. PMID: 36316485 Free PMC article.

6

Design of cell-type-specific hyperstable IL-4 mimetics via modular de novo scaffolds.

Yang H, Ulge UY, Quijano-Rubio A, Bernstein ZJ, Maestas DR, Chun JH, Wang W, Lin JX, Jude KM, Singh S, Orcutt-Jahns BT, Li P, Mou J, Chung L, Kuo YH, Ali YH, Meyer AS, Grayson WL, Heller NM, Garcia KC, Leonard WJ, Silva DA, Elisseeff JH, Baker D, Spangler JB. Yang H, et al. Nat Chem Biol. 2023 Sep;19(9):1127-1137. doi: 10.1038/s41589-023-01313-6. Epub 2023 Apr 6. Nat Chem Biol. 2023. PMID: 37024727 Free PMC article.

7

Discovery of antibodies targeting multipass transmembrane proteins using a suspension cell-based evolutionary approach.

Krohl PJ, Fine J, Yang H, VanDyke D, Ang Z, Kim KB, Thomas-Tikhonenko A, Spangler JB. Krohl PJ, et al. Among authors: yang h. Cell Rep Methods. 2023 Mar 15;3(3):100429. doi: 10.1016/j.crmeth.2023.100429. eCollection 2023 Mar 27. Cell Rep Methods. 2023. PMID: 37056366 Free PMC article.

8

Mechanistic computational modeling of monospecific and bispecific antibodies targeting interleukin-6/8 receptors.

Ray CM, Yang H, Spangler JB, Mac Gabhann F. Ray CM, et al. Among authors: yang h. bioRxiv [Preprint]. 2023 Dec 19:2023.12.18.570445. doi: 10.1101/2023.12.18.570445. bioRxiv. 2023. Update in: PLoS Comput Biol. 2024 Jun 7;20(6):e1012157. doi: 10.1371/journal.pcbi.1012157 PMID: 38187701 Free PMC article. Updated. Preprint.

9

Mechanistic computational modeling of monospecific and bispecific antibodies targeting interleukin-6/8 receptors.

Ray CMP, Yang H, Spangler JB, Mac Gabhann F. Ray CMP, et al. Among authors: yang h. PLoS Comput Biol. 2024 Jun 7;20(6):e1012157. doi: 10.1371/journal.pcbi.1012157. eCollection 2024 Jun. PLoS Comput Biol. 2024. PMID: 38848446 Free PMC article.

10

Preclinical proof of principle for orally delivered Th17 antagonist miniproteins.

Berger S, Seeger F, Yu TY, Aydin M, Yang H, Rosenblum D, Guenin-Macé L, Glassman C, Arguinchona L, Sniezek C, Blackstone A, Carter L, Ravichandran R, Ahlrichs M, Murphy M, Pultz IS, Kang A, Bera AK, Stewart L, Garcia KC, Naik S, Spangler JB, Beigel F, Siebeck M, Gropp R, Baker D. Berger S, et al. Among authors: yang h. Cell. 2024 Aug 8;187(16):4305-4317.e18. doi: 10.1016/j.cell.2024.05.052. Epub 2024 Jun 26. Cell. 2024. PMID: 38936360 Free article.

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