Norris DA - Search Results

1

Bioanalysis considerations on the pharmacokinetic evaluation of antisense therapeutics.

Norris DA, Post N, Yu RZ, Greenlee S, Wang Y. Norris DA, et al. Bioanalysis. 2019 Nov;11(21):1909-1912. doi: 10.4155/bio-2019-0194. Epub 2019 Oct 25. Bioanalysis. 2019. PMID: 31648523 No abstract available.

2

Predictive dose-based estimation of systemic exposure multiples in mouse and monkey relative to human for antisense oligonucleotides with 2'-o-(2-methoxyethyl) modifications.

Yu RZ, Grundy JS, Henry SP, Kim TW, Norris DA, Burkey J, Wang Y, Vick A, Geary RS. Yu RZ, et al. Among authors: norris da. Mol Ther Nucleic Acids. 2015 Jan 20;4(1):e218. doi: 10.1038/mtna.2014.69. Mol Ther Nucleic Acids. 2015. PMID: 25602582 Free PMC article.

3

Pharmacokinetics, biodistribution and cell uptake of antisense oligonucleotides.

Geary RS, Norris D, Yu R, Bennett CF. Geary RS, et al. Adv Drug Deliv Rev. 2015 Jun 29;87:46-51. doi: 10.1016/j.addr.2015.01.008. Epub 2015 Feb 7. Adv Drug Deliv Rev. 2015. PMID: 25666165 Free article. Review.

4

Suppressing transthyretin production in mice, monkeys and humans using 2nd-Generation antisense oligonucleotides.

Ackermann EJ, Guo S, Benson MD, Booten S, Freier S, Hughes SG, Kim TW, Jesse Kwoh T, Matson J, Norris D, Yu R, Watt A, Monia BP. Ackermann EJ, et al. Amyloid. 2016 Sep;23(3):148-157. doi: 10.1080/13506129.2016.1191458. Epub 2016 Jun 29. Amyloid. 2016. PMID: 27355239 Clinical Trial.

5

Population Pharmacokinetics of Nusinersen in the Cerebral Spinal Fluid and Plasma of Pediatric Patients With Spinal Muscular Atrophy Following Intrathecal Administrations.

Luu KT, Norris DA, Gunawan R, Henry S, Geary R, Wang Y. Luu KT, et al. Among authors: norris da. J Clin Pharmacol. 2017 Aug;57(8):1031-1041. doi: 10.1002/jcph.884. Epub 2017 Mar 29. J Clin Pharmacol. 2017. PMID: 28369979

6

Assessment of the Drug Interaction Potential of Unconjugated and GalNAc₃-Conjugated 2'-MOE-ASOs.

Shemesh CS, Yu RZ, Warren MS, Liu M, Jahic M, Nichols B, Post N, Lin S, Norris DA, Hurh E, Huang J, Watanabe T, Henry SP, Wang Y. Shemesh CS, et al. Among authors: norris da. Mol Ther Nucleic Acids. 2017 Dec 15;9:34-47. doi: 10.1016/j.omtn.2017.08.012. Epub 2017 Aug 30. Mol Ther Nucleic Acids. 2017. PMID: 29246313 Free PMC article.

7

Translating Antisense Technology into a Treatment for Huntington's Disease.

Lane RM, Smith A, Baumann T, Gleichmann M, Norris D, Bennett CF, Kordasiewicz H. Lane RM, et al. Methods Mol Biol. 2018;1780:497-523. doi: 10.1007/978-1-4939-7825-0_23. Methods Mol Biol. 2018. PMID: 29856033 Review.

8

A Semi-Mechanistic Population Pharmacokinetic Model of Nusinersen: An Antisense Oligonucleotide for the Treatment of Spinal Muscular Atrophy.

Biliouris K, Gaitonde P, Yin W, Norris DA, Wang Y, Henry S, Fey R, Nestorov I, Schmidt S, Rogge M, Lesko LJ, Trame MN. Biliouris K, et al. Among authors: norris da. CPT Pharmacometrics Syst Pharmacol. 2018 Sep;7(9):581-592. doi: 10.1002/psp4.12323. Epub 2018 Aug 16. CPT Pharmacometrics Syst Pharmacol. 2018. PMID: 30043511 Free PMC article.

9

2018 White Paper on Recent Issues in Bioanalysis: 'A global bioanalytical community perspective on last decade of incurred samples reanalysis (ISR)' (Part 1 - small molecule regulated bioanalysis, small molecule biomarkers, peptides & oligonucleotide bioanalysis).

Welink J, Xu Y, Yang E, Wilson A, Henderson N, Luo L, Fraser S, Kavita U, Musuku A, James C, Fraier D, Zhang Y, Goykhman D, Summerfield S, Woolf E, Verhaeghe T, Hughes N, Behling A, Brown K, Bulychev A, Buonarati M, Cherry E, Cho SJ, Cludts I, Dillen L, Dodge R, Edmison A, Garofolo F, Green R, Haidar S, Hottenstein C, Ishii-Watabe A, Jang HG, Ji A, Jones B, Kassim S, Ma M, Lima Santos GM, Norris DA, Owen T, Piccoli S, Ramanathan R, Röhl I, Rosenbaum AI, Saito Y, Sangster T, Savoie N, Stebbins C, Sydor J, de Merbel NV, Verthelyi D, Vinter S, Whale E. Welink J, et al. Among authors: norris da. Bioanalysis. 2018 Nov 1;10(22):1781-1801. doi: 10.4155/bio-2018-0268. Epub 2018 Nov 29. Bioanalysis. 2018. PMID: 30488725

10

Immunogenicity Assessment of Inotersen, a 2'-O-(2-Methoxyethyl) Antisense Oligonucleotide in Animals and Humans: Effect on Pharmacokinetics, Pharmacodynamics, and Safety.

Yu RZ, Wang Y, Norris DA, Kim TW, Narayanan P, Geary RS, Monia BP, Henry SP. Yu RZ, et al. Among authors: norris da. Nucleic Acid Ther. 2020 Oct;30(5):265-275. doi: 10.1089/nat.2020.0867. Epub 2020 Aug 19. Nucleic Acid Ther. 2020. PMID: 32833564 Clinical Trial.

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