Markham R - Search Results

1

HIV-2/SIV Vpx targets a novel functional domain of STING to selectively inhibit cGAS-STING-mediated NF-κB signalling.

Su J, Rui Y, Lou M, Yin L, Xiong H, Zhou Z, Shen S, Chen T, Zhang Z, Zhao N, Zhang W, Cai Y, Markham R, Zheng S, Xu R, Wei W, Yu XF. Su J, et al. Among authors: markham r. Nat Microbiol. 2019 Dec;4(12):2552-2564. doi: 10.1038/s41564-019-0585-4. Epub 2019 Oct 28. Nat Microbiol. 2019. PMID: 31659299

2

Variation of two primate lineage-specific residues in human SAMHD1 confers resistance to N terminus-targeted SIV Vpx proteins.

Wei W, Guo H, Gao Q, Markham R, Yu XF. Wei W, et al. Among authors: markham r. J Virol. 2014 Jan;88(1):583-91. doi: 10.1128/JVI.02866-13. Epub 2013 Oct 30. J Virol. 2014. PMID: 24173216 Free PMC article.

3

Inhibition of Vpx-Mediated SAMHD1 and Vpr-Mediated Host Helicase Transcription Factor Degradation by Selective Disruption of Viral CRL4 (DCAF1) E3 Ubiquitin Ligase Assembly.

Wang H, Guo H, Su J, Rui Y, Zheng W, Gao W, Zhang W, Li Z, Liu G, Markham RB, Wei W, Yu XF. Wang H, et al. J Virol. 2017 Apr 13;91(9):e00225-17. doi: 10.1128/JVI.00225-17. Print 2017 May 1. J Virol. 2017. PMID: 28202763 Free PMC article.

4

HIV-1 Vpr suppresses the cytomegalovirus promoter in a CRL4(DCAF1) E3 ligase independent manner.

Liu X, Guo H, Wang H, Markham R, Wei W, Yu XF. Liu X, et al. Among authors: markham r. Biochem Biophys Res Commun. 2015 Apr 3;459(2):214-219. doi: 10.1016/j.bbrc.2015.02.060. Epub 2015 Feb 19. Biochem Biophys Res Commun. 2015. PMID: 25704090

5

Accumulation of MxB/Mx2-resistant HIV-1 Capsid Variants During Expansion of the HIV-1 Epidemic in Human Populations.

Wei W, Guo H, Ma M, Markham R, Yu XF. Wei W, et al. Among authors: markham r. EBioMedicine. 2016 Jun;8:230-236. doi: 10.1016/j.ebiom.2016.04.020. Epub 2016 Apr 17. EBioMedicine. 2016. PMID: 27428433 Free PMC article.

6

Disruption of MDA5-Mediated Innate Immune Responses by the 3C Proteins of Coxsackievirus A16, Coxsackievirus A6, and Enterovirus D68.

Rui Y, Su J, Wang H, Chang J, Wang S, Zheng W, Cai Y, Wei W, Gordy JT, Markham R, Kong W, Zhang W, Yu XF. Rui Y, et al. Among authors: markham r. J Virol. 2017 Jun 9;91(13):e00546-17. doi: 10.1128/JVI.00546-17. Print 2017 Jul 1. J Virol. 2017. PMID: 28424289 Free PMC article.

7

The poly-proline tail of SIVmac Vpx provides gain of function for resistance to a cryptic proteasome-dependent degradation pathway.

Zhang N, Guo H, Yang J, Liu G, Li S, Li S, Wang D, Li R, Shu C, Xu H, Wei Z, Huang H, Zhang S, Gao P, Cen S, Markham R, Wang Y, Yu XF, Wei W. Zhang N, et al. Among authors: markham r. Virology. 2017 Nov;511:23-29. doi: 10.1016/j.virol.2017.07.022. Epub 2017 Aug 10. Virology. 2017. PMID: 28803141 Free article.

8

A first-in-class NAE inhibitor, MLN4924, blocks lentiviral infection in myeloid cells by disrupting neddylation-dependent Vpx-mediated SAMHD1 degradation.

Wei W, Guo H, Liu X, Zhang H, Qian L, Luo K, Markham RB, Yu XF. Wei W, et al. J Virol. 2014 Jan;88(1):745-51. doi: 10.1128/JVI.02568-13. Epub 2013 Oct 23. J Virol. 2014. PMID: 24155378 Free PMC article.

9

Circulating HFMD-associated coxsackievirus A16 is genetically and phenotypically distinct from the prototype CV-A16.

Wei W, Guo H, Li J, Ren S, Wei Z, Bao W, Hu X, Zhao K, Zhang W, Zhou Y, Sun F, Markham R, Yu XF. Wei W, et al. Among authors: markham r. PLoS One. 2014 Apr 15;9(4):e94746. doi: 10.1371/journal.pone.0094746. eCollection 2014. PLoS One. 2014. PMID: 24736564 Free PMC article.

10

Analysis of Enterovirus 68 Strains from the 2014 North American Outbreak Reveals a New Clade, Indicating Viral Evolution.

Du J, Zheng B, Zheng W, Li P, Kang J, Hou J, Markham R, Zhao K, Yu XF. Du J, et al. Among authors: markham r. PLoS One. 2015 Dec 2;10(12):e0144208. doi: 10.1371/journal.pone.0144208. eCollection 2015. PLoS One. 2015. PMID: 26630383 Free PMC article.

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