Edwards J - Search Results

1

Discovery and optimization of a series of small-molecule allosteric inhibitors of MALT1 protease.

Lu T, Connolly PJ, Philippar U, Sun W, Cummings MD, Barbay K, Gys L, Van Nuffel L, Austin N, Bekkers M, Shen F, Cai A, Attar R, Meerpoel L, Edwards J. Lu T, et al. Among authors: edwards j. Bioorg Med Chem Lett. 2019 Dec 1;29(23):126743. doi: 10.1016/j.bmcl.2019.126743. Epub 2019 Oct 17. Bioorg Med Chem Lett. 2019. PMID: 31678006

2

Nonpeptidic, noncovalent inhibitors of the cysteine protease cathepsin S.

Thurmond RL, Beavers MP, Cai H, Meduna SP, Gustin DJ, Sun S, Almond HJ, Karlsson L, Edwards JP. Thurmond RL, et al. Among authors: edwards jp. J Med Chem. 2004 Sep 23;47(20):4799-801. doi: 10.1021/jm0496133. J Med Chem. 2004. PMID: 15369380

3

Discovery and SAR studies of a novel series of noncovalent cathepsin S inhibitors.

Gustin DJ, Sehon CA, Wei J, Cai H, Meduna SP, Khatuya H, Sun S, Gu Y, Jiang W, Thurmond RL, Karlsson L, Edwards JP. Gustin DJ, et al. Among authors: edwards jp. Bioorg Med Chem Lett. 2005 Mar 15;15(6):1687-91. doi: 10.1016/j.bmcl.2005.01.045. Bioorg Med Chem Lett. 2005. PMID: 15745822

4

The SAR of 4-substituted (6,6-bicyclic) piperidine cathepsin S inhibitors.

Grice CA, Tays K, Khatuya H, Gustin DJ, Butler CR, Wei J, Sehon CA, Sun S, Gu Y, Jiang W, Thurmond RL, Karlsson L, Edwards JP. Grice CA, et al. Among authors: edwards jp. Bioorg Med Chem Lett. 2006 Apr 15;16(8):2209-12. doi: 10.1016/j.bmcl.2006.01.038. Epub 2006 Feb 3. Bioorg Med Chem Lett. 2006. PMID: 16458510

5

Pyrazole-based arylalkyne cathepsin S inhibitors. Part II: optimization of cellular potency.

Ameriks MK, Cai H, Edwards JP, Gebauer D, Gleason E, Gu Y, Karlsson L, Nguyen S, Sun S, Thurmond RL, Zhu J. Ameriks MK, et al. Among authors: edwards jp. Bioorg Med Chem Lett. 2009 Nov 1;19(21):6135-9. doi: 10.1016/j.bmcl.2009.09.013. Epub 2009 Sep 10. Bioorg Med Chem Lett. 2009. PMID: 19783435

6

Discovery and SAR of novel pyrazole-based thioethers as cathepsin S inhibitors: part 1.

Lee-Dutra A, Wiener DK, Arienti KL, Liu J, Mani N, Ameriks MK, Axe FU, Gebauer D, Desai PJ, Nguyen S, Randal M, Thurmond RL, Sun S, Karlsson L, Edwards JP, Jones TK, Grice CA. Lee-Dutra A, et al. Among authors: edwards jp. Bioorg Med Chem Lett. 2010 Apr 1;20(7):2370-4. doi: 10.1016/j.bmcl.2010.01.108. Epub 2010 Jan 28. Bioorg Med Chem Lett. 2010. PMID: 20153648

7

Discovery and SAR of novel pyrazole-based thioethers as cathepsin S inhibitors. Part 2: Modification of P3, P4, and P5 regions.

Wiener JJ, Wickboldt AT Jr, Wiener DK, Lee-Dutra A, Edwards JP, Karlsson L, Nguyen S, Sun S, Jones TK, Grice CA. Wiener JJ, et al. Among authors: edwards jp. Bioorg Med Chem Lett. 2010 Apr 1;20(7):2375-8. doi: 10.1016/j.bmcl.2010.01.104. Epub 2010 Feb 1. Bioorg Med Chem Lett. 2010. PMID: 20171097

8

Thioether acetamides as P3 binding elements for tetrahydropyrido-pyrazole cathepsin S inhibitors.

Wiener DK, Lee-Dutra A, Bembenek S, Nguyen S, Thurmond RL, Sun S, Karlsson L, Grice CA, Jones TK, Edwards JP. Wiener DK, et al. Bioorg Med Chem Lett. 2010 Apr 1;20(7):2379-82. doi: 10.1016/j.bmcl.2010.01.103. Epub 2010 Feb 8. Bioorg Med Chem Lett. 2010. PMID: 20188543

9

Tricyclic aminopyrimidine histamine H4 receptor antagonists.

Savall BM, Gomez L, Chavez F, Curtis M, Meduna SP, Kearney A, Dunford P, Cowden J, Thurmond RL, Grice C, Edwards JP. Savall BM, et al. Among authors: edwards jp. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6577-81. doi: 10.1016/j.bmcl.2011.08.014. Epub 2011 Aug 19. Bioorg Med Chem Lett. 2011. PMID: 21920744

10

Pyrazole-based arylalkyne cathepsin S inhibitors. Part III: modification of P4 region.

Wiener JJ, Wickboldt AT, Nguyen S, Sun S, Rynberg R, Rizzolio M, Karlsson L, Edwards JP, Grice CA. Wiener JJ, et al. Among authors: edwards jp. Bioorg Med Chem Lett. 2013 Feb 15;23(4):1070-4. doi: 10.1016/j.bmcl.2012.12.014. Epub 2012 Dec 21. Bioorg Med Chem Lett. 2013. PMID: 23313244

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