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In Vivo Efficacy of Meropenem with a Novel Non-β-Lactam-β-Lactamase Inhibitor, Nacubactam, against Gram-Negative Organisms Exhibiting Various Resistance Mechanisms in a Murine Complicated Urinary Tract Infection Model.
Monogue ML, Giovagnoli S, Bissantz C, Zampaloni C, Nicolau DP. Monogue ML, et al. Among authors: bissantz c. Antimicrob Agents Chemother. 2018 Aug 27;62(9):e02596-17. doi: 10.1128/AAC.02596-17. Print 2018 Sep. Antimicrob Agents Chemother. 2018. PMID: 30012751 Free PMC article.
Efficacy of Human-Simulated Epithelial Lining Fluid Exposure of Meropenem-Nacubactam Combination against Class A Serine β-Lactamase-Producing Enterobacteriaceae in the Neutropenic Murine Lung Infection Model.
Asempa TE, Motos A, Abdelraouf K, Bissantz C, Zampaloni C, Nicolau DP. Asempa TE, et al. Among authors: bissantz c. Antimicrob Agents Chemother. 2019 Mar 27;63(4):e02382-18. doi: 10.1128/AAC.02382-18. Print 2019 Apr. Antimicrob Agents Chemother. 2019. PMID: 30670411 Free PMC article.
Discovery of RO7185876, a Highly Potent γ-Secretase Modulator (GSM) as a Potential Treatment for Alzheimer's Disease.
Ratni H, Alker A, Bartels B, Bissantz C, Chen W, Gerlach I, Limberg A, Lu M, Neidhart W, Pichereau S, Reutlinger M, Rodriguez-Sarmiento RM, Jakob-Roetne R, Schmitt G, Zhang E, Baumann K. Ratni H, et al. Among authors: bissantz c. ACS Med Chem Lett. 2020 Apr 27;11(6):1257-1268. doi: 10.1021/acsmedchemlett.0c00109. eCollection 2020 Jun 11. ACS Med Chem Lett. 2020. PMID: 32551009 Free PMC article.
Discovery of Balovaptan, a Vasopressin 1a Receptor Antagonist for the Treatment of Autism Spectrum Disorder.
Schnider P, Bissantz C, Bruns A, Dolente C, Goetschi E, Jakob-Roetne R, Künnecke B, Mueggler T, Muster W, Parrott N, Pinard E, Ratni H, Risterucci C, Rogers-Evans M, von Kienlin M, Grundschober C. Schnider P, et al. Among authors: bissantz c. J Med Chem. 2020 Feb 27;63(4):1511-1525. doi: 10.1021/acs.jmedchem.9b01478. Epub 2020 Jan 17. J Med Chem. 2020. PMID: 31951127
Translating pharmacology models effectively to predict therapeutic benefit.
Dudal S, Bissantz C, Caruso A, David-Pierson P, Driessen W, Koller E, Krippendorff BF, Lechmann M, Olivares-Morales A, Paehler A, Rynn C, Türck D, Van De Vyver A, Wang K, Winther L. Dudal S, et al. Among authors: bissantz c. Drug Discov Today. 2022 Jun;27(6):1604-1621. doi: 10.1016/j.drudis.2022.03.009. Epub 2022 Mar 15. Drug Discov Today. 2022. PMID: 35304340 Free article. Review.
A medicinal chemist's guide to molecular interactions.
Bissantz C, Kuhn B, Stahl M. Bissantz C, et al. J Med Chem. 2010 Jul 22;53(14):5061-84. doi: 10.1021/jm100112j. J Med Chem. 2010. PMID: 20345171 Free PMC article. Review. No abstract available.
43 results