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Protein-coding variants contribute to the risk of atopic dermatitis and skin-specific gene expression.
Mucha S, Baurecht H, Novak N, Rodríguez E, Bej S, Mayr G, Emmert H, Stölzl D, Gerdes S, Jung ES, Degenhardt F, Hübenthal M, Ellinghaus E, Kässens JC, Wienbrandt L, Lieb W, Müller-Nurasyid M, Hotze M, Dand N, Grosche S, Marenholz I, Arnold A, Homuth G, Schmidt CO, Wehkamp U, Nöthen MM, Hoffmann P, Paternoster L, Standl M; Early Genetics and Lifecourse Epidemiology (EAGLE) Eczema Consortium; Bønnelykke K, Ahluwalia TS, Bisgaard H, Peters A, Gieger C, Waldenberger M, Schulz H, Strauch K, Werfel T, Lee YA, Wolfien M, Rosenstiel P, Wolkenhauer O, Schreiber S, Franke A, Weidinger S, Ellinghaus D. Mucha S, et al. Among authors: rodriguez e. J Allergy Clin Immunol. 2020 Apr;145(4):1208-1218. doi: 10.1016/j.jaci.2019.10.030. Epub 2019 Nov 9. J Allergy Clin Immunol. 2020. PMID: 31707051
Loss-of-function variations within the filaggrin gene predispose for atopic dermatitis with allergic sensitizations.
Weidinger S, Illig T, Baurecht H, Irvine AD, Rodriguez E, Diaz-Lacava A, Klopp N, Wagenpfeil S, Zhao Y, Liao H, Lee SP, Palmer CN, Jenneck C, Maintz L, Hagemann T, Behrendt H, Ring J, Nothen MM, McLean WH, Novak N. Weidinger S, et al. Among authors: rodriguez e. J Allergy Clin Immunol. 2006 Jul;118(1):214-9. doi: 10.1016/j.jaci.2006.05.004. Epub 2006 Jun 9. J Allergy Clin Immunol. 2006. PMID: 16815158
Filaggrin mutations, atopic eczema, hay fever, and asthma in children.
Weidinger S, O'Sullivan M, Illig T, Baurecht H, Depner M, Rodriguez E, Ruether A, Klopp N, Vogelberg C, Weiland SK, McLean WH, von Mutius E, Irvine AD, Kabesch M. Weidinger S, et al. Among authors: rodriguez e. J Allergy Clin Immunol. 2008 May;121(5):1203-1209.e1. doi: 10.1016/j.jaci.2008.02.014. Epub 2008 Apr 8. J Allergy Clin Immunol. 2008. PMID: 18396323
Analysis of the individual and aggregate genetic contributions of previously identified serine peptidase inhibitor Kazal type 5 (SPINK5), kallikrein-related peptidase 7 (KLK7), and filaggrin (FLG) polymorphisms to eczema risk.
Weidinger S, Baurecht H, Wagenpfeil S, Henderson J, Novak N, Sandilands A, Chen H, Rodriguez E, O'Regan GM, Watson R, Liao H, Zhao Y, Barker JN, Allen M, Reynolds N, Meggitt S, Northstone K, Smith GD, Strobl C, Stahl C, Kneib T, Klopp N, Bieber T, Behrendt H, Palmer CN, Wichmann HE, Ring J, Illig T, McLean WH, Irvine AD. Weidinger S, et al. Among authors: rodriguez e. J Allergy Clin Immunol. 2008 Sep;122(3):560-8.e4. doi: 10.1016/j.jaci.2008.05.050. J Allergy Clin Immunol. 2008. PMID: 18774391
Genome-wide scan on total serum IgE levels identifies FCER1A as novel susceptibility locus.
Weidinger S, Gieger C, Rodriguez E, Baurecht H, Mempel M, Klopp N, Gohlke H, Wagenpfeil S, Ollert M, Ring J, Behrendt H, Heinrich J, Novak N, Bieber T, Krämer U, Berdel D, von Berg A, Bauer CP, Herbarth O, Koletzko S, Prokisch H, Mehta D, Meitinger T, Depner M, von Mutius E, Liang L, Moffatt M, Cookson W, Kabesch M, Wichmann HE, Illig T. Weidinger S, et al. Among authors: rodriguez e. PLoS Genet. 2008 Aug;4(8):e1000166. doi: 10.1371/journal.pgen.1000166. Epub 2008 Aug 22. PLoS Genet. 2008. PMID: 18846228 Free PMC article.
A common variant on chromosome 11q13 is associated with atopic dermatitis.
Esparza-Gordillo J, Weidinger S, Fölster-Holst R, Bauerfeind A, Ruschendorf F, Patone G, Rohde K, Marenholz I, Schulz F, Kerscher T, Hubner N, Wahn U, Schreiber S, Franke A, Vogler R, Heath S, Baurecht H, Novak N, Rodriguez E, Illig T, Lee-Kirsch MA, Ciechanowicz A, Kurek M, Piskackova T, Macek M, Lee YA, Ruether A. Esparza-Gordillo J, et al. Among authors: rodriguez e. Nat Genet. 2009 May;41(5):596-601. doi: 10.1038/ng.347. Epub 2009 Apr 6. Nat Genet. 2009. PMID: 19349984
3,950 results