Meagher JL - Search Results

1

A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo.

Bai L, Zhou H, Xu R, Zhao Y, Chinnaswamy K, McEachern D, Chen J, Yang CY, Liu Z, Wang M, Liu L, Jiang H, Wen B, Kumar P, Meagher JL, Sun D, Stuckey JA, Wang S. Bai L, et al. Among authors: meagher jl. Cancer Cell. 2019 Nov 11;36(5):498-511.e17. doi: 10.1016/j.ccell.2019.10.002. Cancer Cell. 2019. PMID: 31715132 Free PMC article.

2

Crystal structure of banana lectin reveals a novel second sugar binding site.

Meagher JL, Winter HC, Ezell P, Goldstein IJ, Stuckey JA. Meagher JL, et al. Glycobiology. 2005 Oct;15(10):1033-42. doi: 10.1093/glycob/cwi088. Epub 2005 Jun 8. Glycobiology. 2005. PMID: 15944373

3

Structure-based design of potent small-molecule inhibitors of anti-apoptotic Bcl-2 proteins.

Wang G, Nikolovska-Coleska Z, Yang CY, Wang R, Tang G, Guo J, Shangary S, Qiu S, Gao W, Yang D, Meagher J, Stuckey J, Krajewski K, Jiang S, Roller PP, Abaan HO, Tomita Y, Wang S. Wang G, et al. J Med Chem. 2006 Oct 19;49(21):6139-42. doi: 10.1021/jm060460o. J Med Chem. 2006. PMID: 17034116

4

Design, synthesis, and evaluation of a potent, cell-permeable, conformationally constrained second mitochondria derived activator of caspase (Smac) mimetic.

Sun H, Nikolovska-Coleska Z, Lu J, Qiu S, Yang CY, Gao W, Meagher J, Stuckey J, Wang S. Sun H, et al. J Med Chem. 2006 Dec 28;49(26):7916-20. doi: 10.1021/jm061108d. J Med Chem. 2006. PMID: 17181177

5

Structure-based design of flavonoid compounds as a new class of small-molecule inhibitors of the anti-apoptotic Bcl-2 proteins.

Tang G, Ding K, Nikolovska-Coleska Z, Yang CY, Qiu S, Shangary S, Wang R, Guo J, Gao W, Meagher J, Stuckey J, Krajewski K, Jiang S, Roller PP, Wang S. Tang G, et al. J Med Chem. 2007 Jul 12;50(14):3163-6. doi: 10.1021/jm070383c. Epub 2007 Jun 7. J Med Chem. 2007. PMID: 17552510 Free PMC article.

6

Design, synthesis, and characterization of a potent, nonpeptide, cell-permeable, bivalent Smac mimetic that concurrently targets both the BIR2 and BIR3 domains in XIAP.

Sun H, Nikolovska-Coleska Z, Lu J, Meagher JL, Yang CY, Qiu S, Tomita Y, Ueda Y, Jiang S, Krajewski K, Roller PP, Stuckey JA, Wang S. Sun H, et al. Among authors: meagher jl. J Am Chem Soc. 2007 Dec 12;129(49):15279-94. doi: 10.1021/ja074725f. Epub 2007 Nov 14. J Am Chem Soc. 2007. PMID: 17999504 Free PMC article.

7

Design and characterization of bivalent Smac-based peptides as antagonists of XIAP and development and validation of a fluorescence polarization assay for XIAP containing both BIR2 and BIR3 domains.

Nikolovska-Coleska Z, Meagher JL, Jiang S, Kawamoto SA, Gao W, Yi H, Qin D, Roller PP, Stuckey JA, Wang S. Nikolovska-Coleska Z, et al. Among authors: meagher jl. Anal Biochem. 2008 Mar 1;374(1):87-98. doi: 10.1016/j.ab.2007.10.032. Epub 2007 Nov 20. Anal Biochem. 2008. PMID: 18023397

8

Interaction of a cyclic, bivalent smac mimetic with the x-linked inhibitor of apoptosis protein.

Nikolovska-Coleska Z, Meagher JL, Jiang S, Yang CY, Qiu S, Roller PP, Stuckey JA, Wang S. Nikolovska-Coleska Z, et al. Among authors: meagher jl. Biochemistry. 2008 Sep 16;47(37):9811-24. doi: 10.1021/bi800785y. Epub 2008 Aug 22. Biochemistry. 2008. PMID: 18717598 Free PMC article.

9

Structure-based design, synthesis, evaluation, and crystallographic studies of conformationally constrained Smac mimetics as inhibitors of the X-linked inhibitor of apoptosis protein (XIAP).

Sun H, Stuckey JA, Nikolovska-Coleska Z, Qin D, Meagher JL, Qiu S, Lu J, Yang CY, Saito NG, Wang S. Sun H, et al. Among authors: meagher jl. J Med Chem. 2008 Nov 27;51(22):7169-80. doi: 10.1021/jm8006849. J Med Chem. 2008. PMID: 18954041 Free PMC article.

10

SM-164: a novel, bivalent Smac mimetic that induces apoptosis and tumor regression by concurrent removal of the blockade of cIAP-1/2 and XIAP.

Lu J, Bai L, Sun H, Nikolovska-Coleska Z, McEachern D, Qiu S, Miller RS, Yi H, Shangary S, Sun Y, Meagher JL, Stuckey JA, Wang S. Lu J, et al. Among authors: meagher jl. Cancer Res. 2008 Nov 15;68(22):9384-93. doi: 10.1158/0008-5472.CAN-08-2655. Cancer Res. 2008. PMID: 19010913 Free PMC article.

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