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Importance of thorough tissue and cellular level characterization of targeted drugs in the evaluation of pharmacodynamic effects.
Bauknight DK, Osinski V, Dasa SSK, Nguyen AT, Marshall MA, Hartman J, Harms M, O'Mahony G, Boucher J, Klibanov AL, McNamara CA, Kelly KA. Bauknight DK, et al. Among authors: klibanov al. PLoS One. 2019 Nov 14;14(11):e0224917. doi: 10.1371/journal.pone.0224917. eCollection 2019. PLoS One. 2019. PMID: 31725756 Free PMC article.
Inhibitor of differentiation-3 mediates high fat diet-induced visceral fat expansion.
Cutchins A, Harmon DB, Kirby JL, Doran AC, Oldham SN, Skaflen M, Klibanov AL, Meller N, Keller SR, Garmey J, McNamara CA. Cutchins A, et al. Among authors: klibanov al. Arterioscler Thromb Vasc Biol. 2012 Feb;32(2):317-24. doi: 10.1161/ATVBAHA.111.234856. Epub 2011 Nov 10. Arterioscler Thromb Vasc Biol. 2012. PMID: 22075252 Free PMC article.
Klf4 has an unexpected protective role in perivascular cells within the microvasculature.
Haskins RM, Nguyen AT, Alencar GF, Billaud M, Kelly-Goss MR, Good ME, Bottermann K, Klibanov AL, French BA, Harris TE, Peirce SM, Isakson BE, Owens GK. Haskins RM, et al. Among authors: klibanov al. Am J Physiol Heart Circ Physiol. 2018 Aug 1;315(2):H402-H414. doi: 10.1152/ajpheart.00084.2018. Epub 2018 Apr 6. Am J Physiol Heart Circ Physiol. 2018. PMID: 29631369 Free PMC article.
In vivo liposomal delivery of PPARα/γ dual agonist tesaglitazar in a model of obesity enriches macrophage targeting and limits liver and kidney drug effects.
Osinski V, Bauknight DK, Dasa SSK, Harms MJ, Kroon T, Marshall MA, Garmey JC, Nguyen AT, Hartman J, Upadhye A, Srikakulapu P, Zhou A, O'Mahony G, Klibanov AL, Kelly KA, Boucher J, McNamara CA. Osinski V, et al. Among authors: klibanov al. Theranostics. 2020 Jan 1;10(2):585-601. doi: 10.7150/thno.36572. eCollection 2020. Theranostics. 2020. PMID: 31903139 Free PMC article.
Deformable gas-filled microbubbles targeted to P-selectin.
Rychak JJ, Lindner JR, Ley K, Klibanov AL. Rychak JJ, et al. Among authors: klibanov al. J Control Release. 2006 Sep 12;114(3):288-99. doi: 10.1016/j.jconrel.2006.06.008. Epub 2006 Jun 14. J Control Release. 2006. PMID: 16887229
212 results