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A Potent Blood-Brain Barrier-Permeable Mutant IDH1 Inhibitor Suppresses the Growth of Glioblastoma with IDH1 Mutation in a Patient-Derived Orthotopic Xenograft Model.
Machida Y, Nakagawa M, Matsunaga H, Yamaguchi M, Ogawara Y, Shima Y, Yamagata K, Katsumoto T, Hattori A, Itoh M, Seki T, Nishiya Y, Nakamura K, Suzuki K, Imaoka T, Baba D, Suzuki M, Sampetrean O, Saya H, Ichimura K, Kitabayashi I. Machida Y, et al. Among authors: suzuki k, suzuki m. Mol Cancer Ther. 2020 Feb;19(2):375-383. doi: 10.1158/1535-7163.MCT-18-1349. Epub 2019 Nov 14. Mol Cancer Ther. 2020. PMID: 31727689
A novel Menin-MLL1 inhibitor, DS-1594a, prevents the progression of acute leukemia with rearranged MLL1 or mutated NPM1.
Numata M, Haginoya N, Shiroishi M, Hirata T, Sato-Otsubo A, Yoshikawa K, Takata Y, Nagase R, Kashimoto Y, Suzuki M, Schulte N, Polier G, Kurimoto A, Tomoe Y, Toyota A, Yoneyama T, Imai E, Watanabe K, Hamada T, Kanada R, Watanabe J, Kagoshima Y, Tokumaru E, Murata K, Baba T, Shinozaki T, Ohtsuka M, Goto K, Karibe T, Deguchi T, Gocho Y, Yoshida M, Tomizawa D, Kato M, Tsutsumi S, Kitagawa M, Abe Y. Numata M, et al. Among authors: suzuki m. Cancer Cell Int. 2023 Feb 25;23(1):36. doi: 10.1186/s12935-023-02877-y. Cancer Cell Int. 2023. PMID: 36841758 Free PMC article.
Structure of N-myristoyltransferase from Aspergillus fumigatus.
Shimada T, Suzuki M, Katakura S. Shimada T, et al. Among authors: suzuki m. Acta Crystallogr D Biol Crystallogr. 2015 Apr;71(Pt 4):754-61. doi: 10.1107/S1399004715000401. Epub 2015 Mar 26. Acta Crystallogr D Biol Crystallogr. 2015. PMID: 25849386
Discovery of DS79932728: A Potent, Orally Available G9a/GLP Inhibitor for Treating β-Thalassemia and Sickle Cell Disease.
Katayama K, Ishii K, Terashima H, Tsuda E, Suzuki M, Yotsumoto K, Hiramoto K, Yasumatsu I, Torihata M, Ishiyama T, Muto T, Katagiri T. Katayama K, et al. Among authors: suzuki m. ACS Med Chem Lett. 2020 Dec 28;12(1):121-128. doi: 10.1021/acsmedchemlett.0c00572. eCollection 2021 Jan 14. ACS Med Chem Lett. 2020. PMID: 33488973 Free PMC article.
Discovery of novel histone lysine methyltransferase G9a/GLP (EHMT2/1) inhibitors: Design, synthesis, and structure-activity relationships of 2,4-diamino-6-methylpyrimidines.
Katayama K, Ishii K, Tsuda E, Yotsumoto K, Hiramoto K, Suzuki M, Yasumatsu I, Igarashi W, Torihata M, Ishiyama T, Katagiri T. Katayama K, et al. Among authors: suzuki m. Bioorg Med Chem Lett. 2020 Oct 15;30(20):127475. doi: 10.1016/j.bmcl.2020.127475. Epub 2020 Aug 8. Bioorg Med Chem Lett. 2020. PMID: 32781218
Discovery of N-[(1R,2S,5S)-2-{[(5-chloroindol-2-yl)carbonyl]amino}-5-(dimethylcarbamoyl)cyclohexyl]-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxamide hydrochloride: a novel, potent and orally active direct inhibitor of factor Xa.
Nagata T, Yoshino T, Haginoya N, Yoshikawa K, Nagamochi M, Kobayashi S, Komoriya S, Yokomizo A, Muto R, Yamaguchi M, Osanai K, Suzuki M, Kanno H. Nagata T, et al. Among authors: suzuki m. Bioorg Med Chem. 2009 Feb 1;17(3):1193-206. doi: 10.1016/j.bmc.2008.12.037. Epub 2008 Dec 24. Bioorg Med Chem. 2009. PMID: 19128974
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