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Short Communication: Metformin Reduces CD4 T Cell Exhaustion in HIV-Infected Adults on Suppressive Antiretroviral Therapy.
Shikuma CM, Chew GM, Kohorn L, Souza SA, Chow D, SahBandar IN, Park EY, Hanks N, Gangcuangco LMA, Gerschenson M, Ndhlovu LC. Shikuma CM, et al. Among authors: chew gm. AIDS Res Hum Retroviruses. 2020 Apr;36(4):303-305. doi: 10.1089/AID.2019.0078. Epub 2020 Jan 8. AIDS Res Hum Retroviruses. 2020. PMID: 31731885 Free PMC article. Clinical Trial.
Effects of Brief Adjunctive Metformin Therapy in Virologically Suppressed HIV-Infected Adults on Polyfunctional HIV-Specific CD8 T Cell Responses to PD-L1 Blockade.
Chew GM, Padua AJP, Chow DC, Souza SA, Clements DM, Corley MJ, Pang APS, Alejandria MM, Gerschenson M, Shikuma CM, Ndhlovu LC. Chew GM, et al. AIDS Res Hum Retroviruses. 2021 Jan;37(1):24-33. doi: 10.1089/AID.2020.0172. Epub 2020 Nov 5. AIDS Res Hum Retroviruses. 2021. PMID: 33019813 Free PMC article. Clinical Trial.
Immunologic Change over 72 Weeks Following Raltegravir- Versus Efavirenz-Based Therapy in HIV/HCV-Coinfected Individuals in Vietnam.
Shikuma CM, Le T, Phuong TV, Chew GM, Nguyen VVC, Vo TL, Siriwardhana C, Chow D, Ghukasyan H, Limpruttidham N, Premeaux T, Gangcuangco LM, Paul R, Ndhlovu LC. Shikuma CM, et al. Among authors: chew gm. AIDS Res Hum Retroviruses. 2022 Jun;38(6):441-450. doi: 10.1089/AID.2021.0076. Epub 2022 Jan 13. AIDS Res Hum Retroviruses. 2022. PMID: 34861767 Free PMC article. Clinical Trial.
Galectin-9 is rapidly released during acute HIV-1 infection and remains sustained at high levels despite viral suppression even in elite controllers.
Tandon R, Chew GM, Byron MM, Borrow P, Niki T, Hirashima M, Barbour JD, Norris PJ, Lanteri MC, Martin JN, Deeks SG, Ndhlovu LC. Tandon R, et al. Among authors: chew gm. AIDS Res Hum Retroviruses. 2014 Jul;30(7):654-64. doi: 10.1089/AID.2014.0004. Epub 2014 May 28. AIDS Res Hum Retroviruses. 2014. PMID: 24786365 Free PMC article.
Red blood cell distribution width as an easily measurable biomarker of persistent inflammation and T cell dysregulation in antiretrovirally treated HIV-infected adults.
Zhang Z, Chew GM, Shikuma CM, Gangcuangco LMA, Souza SA, Shiramizu B, Nakamoto BK, Gong T, Mannem SR, Mitchell BI, Kallianpur KJ, Ndhlovu LC, Chow DC. Zhang Z, et al. Among authors: chew gm. HIV Clin Trials. 2018 Oct;19(5):172-176. doi: 10.1080/15284336.2018.1514821. Epub 2018 Nov 13. HIV Clin Trials. 2018. PMID: 30422099 Free PMC article.
Mitochondrial oxidative phosphorylation in peripheral blood mononuclear cells is decreased in chronic HIV and correlates with immune dysregulation.
Gangcuangco LMA, Mitchell BI, Siriwardhana C, Kohorn LB, Chew GM, Bowler S, Kallianpur KJ, Chow DC, Ndhlovu LC, Gerschenson M, Shikuma CM. Gangcuangco LMA, et al. Among authors: chew gm. PLoS One. 2020 Apr 30;15(4):e0231761. doi: 10.1371/journal.pone.0231761. eCollection 2020. PLoS One. 2020. PMID: 32353005 Free PMC article.
Treatment intensification with maraviroc (CCR5 antagonist) leads to declines in CD16-expressing monocytes in cART-suppressed chronic HIV-infected subjects and is associated with improvements in neurocognitive test performance: implications for HIV-associated neurocognitive disease (HAND).
Ndhlovu LC, Umaki T, Chew GM, Chow DC, Agsalda M, Kallianpur KJ, Paul R, Zhang G, Ho E, Hanks N, Nakamoto B, Shiramizu BT, Shikuma CM. Ndhlovu LC, et al. Among authors: chew gm. J Neurovirol. 2014 Dec;20(6):571-82. doi: 10.1007/s13365-014-0279-x. Epub 2014 Sep 17. J Neurovirol. 2014. PMID: 25227930 Free PMC article.
TIGIT Marks Exhausted T Cells, Correlates with Disease Progression, and Serves as a Target for Immune Restoration in HIV and SIV Infection.
Chew GM, Fujita T, Webb GM, Burwitz BJ, Wu HL, Reed JS, Hammond KB, Clayton KL, Ishii N, Abdel-Mohsen M, Liegler T, Mitchell BI, Hecht FM, Ostrowski M, Shikuma CM, Hansen SG, Maurer M, Korman AJ, Deeks SG, Sacha JB, Ndhlovu LC. Chew GM, et al. PLoS Pathog. 2016 Jan 7;12(1):e1005349. doi: 10.1371/journal.ppat.1005349. eCollection 2016 Jan. PLoS Pathog. 2016. PMID: 26741490 Free PMC article.
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