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Page 1
Structure of an endosomal signaling GPCR-G protein-β-arrestin megacomplex.
Nguyen AH, Thomsen ARB, Cahill TJ 3rd, Huang R, Huang LY, Marcink T, Clarke OB, Heissel S, Masoudi A, Ben-Hail D, Samaan F, Dandey VP, Tan YZ, Hong C, Mahoney JP, Triest S, Little J 4th, Chen X, Sunahara R, Steyaert J, Molina H, Yu Z, des Georges A, Lefkowitz RJ. Nguyen AH, et al. Among authors: des georges a. Nat Struct Mol Biol. 2019 Dec;26(12):1123-1131. doi: 10.1038/s41594-019-0330-y. Epub 2019 Nov 18. Nat Struct Mol Biol. 2019. PMID: 31740855 Free PMC article.
Affinity grid-based cryo-EM of PKC binding to RACK1 on the ribosome.
Sharma G, Pallesen J, Das S, Grassucci R, Langlois R, Hampton CM, Kelly DF, des Georges A, Frank J. Sharma G, et al. Among authors: des georges a. J Struct Biol. 2013 Feb;181(2):190-4. doi: 10.1016/j.jsb.2012.11.006. Epub 2012 Dec 8. J Struct Biol. 2013. PMID: 23228487 Free PMC article.
High-resolution cryo-electron microscopy structure of the Trypanosoma brucei ribosome.
Hashem Y, des Georges A, Fu J, Buss SN, Jossinet F, Jobe A, Zhang Q, Liao HY, Grassucci RA, Bajaj C, Westhof E, Madison-Antenucci S, Frank J. Hashem Y, et al. Among authors: des georges a. Nature. 2013 Feb 21;494(7437):385-9. doi: 10.1038/nature11872. Epub 2013 Feb 10. Nature. 2013. PMID: 23395961 Free PMC article.
Structure of a mammalian ryanodine receptor.
Zalk R, Clarke OB, des Georges A, Grassucci RA, Reiken S, Mancia F, Hendrickson WA, Frank J, Marks AR. Zalk R, et al. Among authors: des georges a. Nature. 2015 Jan 1;517(7532):44-9. doi: 10.1038/nature13950. Epub 2014 Dec 1. Nature. 2015. PMID: 25470061 Free PMC article.
Structural Basis for Gating and Activation of RyR1.
des Georges A, Clarke OB, Zalk R, Yuan Q, Condon KJ, Grassucci RA, Hendrickson WA, Marks AR, Frank J. des Georges A, et al. Cell. 2016 Sep 22;167(1):145-157.e17. doi: 10.1016/j.cell.2016.08.075. Cell. 2016. PMID: 27662087 Free PMC article.
Routine single particle CryoEM sample and grid characterization by tomography.
Noble AJ, Dandey VP, Wei H, Brasch J, Chase J, Acharya P, Tan YZ, Zhang Z, Kim LY, Scapin G, Rapp M, Eng ET, Rice WJ, Cheng A, Negro CJ, Shapiro L, Kwong PD, Jeruzalmi D, des Georges A, Potter CS, Carragher B. Noble AJ, et al. Among authors: des georges a. Elife. 2018 May 29;7:e34257. doi: 10.7554/eLife.34257. Elife. 2018. PMID: 29809143 Free PMC article.
Retrieving functional pathways of biomolecules from single-particle snapshots.
Dashti A, Mashayekhi G, Shekhar M, Ben Hail D, Salah S, Schwander P, des Georges A, Singharoy A, Frank J, Ourmazd A. Dashti A, et al. Among authors: des georges a. Nat Commun. 2020 Sep 18;11(1):4734. doi: 10.1038/s41467-020-18403-x. Nat Commun. 2020. PMID: 32948759 Free PMC article.
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