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PROKR2 mutations in idiopathic hypogonadotropic hypogonadism: selective disruption of the binding to a Gα-protein leads to biased signaling.
Zhao Y, Wu J, Jia H, Wang X, Zheng R, Jiang F, Chen DN, Chen Z, Li JD. Zhao Y, et al. FASEB J. 2019 Mar;33(3):4538-4546. doi: 10.1096/fj.201801575R. Epub 2018 Dec 21. FASEB J. 2019. PMID: 30576231
Our results indicated that selective disruption of the interaction with a specific Galpha-protein might underlie the biased signaling for certain IHH-associated PROKR2 mutations.-Zhao, Y., Wu, J., Jia, H., Wang, X., Zheng, R., Jiang, F., Chen, D.-N., Chen, Z., Li, J …
Our results indicated that selective disruption of the interaction with a specific Galpha-protein might underlie the biased signaling for ce …
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