Zhang Y - Search Results

1

p300/CBP inhibitor A-485 alleviates acute liver injury by regulating macrophage activation and polarization.

Peng J, Li J, Huang J, Xu P, Huang H, Liu Y, Yu L, Yang Y, Zhou B, Jiang H, Chen K, Dang Y, Zhang Y, Luo C, Li G. Peng J, et al. Among authors: zhang y. Theranostics. 2019 Oct 22;9(26):8344-8361. doi: 10.7150/thno.30707. eCollection 2019. Theranostics. 2019. PMID: 31754401 Free PMC article.

2

Euphorbia factor L2 alleviates lipopolysaccharide-induced acute lung injury and inflammation in mice through the suppression of NF-κB activation.

Zhang Q, Zhu S, Cheng X, Lu C, Tao W, Zhang Y, William BC, Cao X, Yi S, Liu Y, Zhao Y, Luo Y. Zhang Q, et al. Among authors: zhang y. Biochem Pharmacol. 2018 Sep;155:444-454. doi: 10.1016/j.bcp.2018.07.025. Epub 2018 Jul 26. Biochem Pharmacol. 2018. PMID: 30055150

3

Discovery and biological evaluation of thiobarbituric derivatives as potent p300/CBP inhibitors.

Lu W, Xiong H, Chen Y, Wang C, Zhang H, Xu P, Han J, Xiao S, Ding H, Chen Z, Lu T, Wang J, Zhang Y, Yue L, Liu YC, Zhang C, Yang Y, Jiang H, Chen K, Zhou B, Luo C. Lu W, et al. Among authors: zhang c, zhang h, zhang y. Bioorg Med Chem. 2018 Nov 1;26(20):5397-5407. doi: 10.1016/j.bmc.2018.07.048. Epub 2018 Jul 27. Bioorg Med Chem. 2018. PMID: 30297119

4

Development and evaluation of a novel series of Nitroxoline-derived BET inhibitors with antitumor activity in renal cell carcinoma.

Chen W, Zhang H, Chen Z, Jiang H, Liao L, Fan S, Xing J, Xie Y, Chen S, Ding H, Chen K, Jiang H, Luo C, Zheng M, Yao Z, Huang Y, Zhang Y. Chen W, et al. Among authors: zhang h, zhang y. Oncogenesis. 2018 Nov 2;7(11):83. doi: 10.1038/s41389-018-0093-z. Oncogenesis. 2018. PMID: 30385738 Free PMC article.

5

Discovery of 2-substituted-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-1,2,3,4-tetrahydroisoquinoline-6-carboxamide as potent and selective protein arginine methyltransferases 5 inhibitors: Design, synthesis and biological evaluation.

Shao J, Zhu K, Du D, Zhang Y, Tao H, Chen Z, Jiang H, Chen K, Luo C, Duan W. Shao J, et al. Among authors: zhang y. Eur J Med Chem. 2019 Feb 15;164:317-333. doi: 10.1016/j.ejmech.2018.12.065. Epub 2018 Dec 26. Eur J Med Chem. 2019. PMID: 30605830

6

Reduced asymmetric dimethylarginine accumulation through inhibition of the type I protein arginine methyltransferases promotes renal fibrosis in obstructed kidneys.

Wu M, Lin P, Li L, Chen D, Yang X, Xu L, Zhou B, Wang C, Zhang Y, Luo C, Ye C. Wu M, et al. Among authors: zhang y. FASEB J. 2019 Jun;33(6):6948-6956. doi: 10.1096/fj.201802585RR. Epub 2019 Mar 6. FASEB J. 2019. PMID: 30840839

-Wu, M., Lin, P., Li, L., Chen, D., Yang, X., Xu, L., Zhou, B., Wang, C., Zhang, Y., Luo, C., Ye, C. Reduced asymmetric dimethylarginine accumulation through inhibition of the type I protein arginine methyltransferases promotes renal fibrosis in obstructed kidneys.. …

-Wu, M., Lin, P., Li, L., Chen, D., Yang, X., Xu, L., Zhou, B., Wang, C., Zhang, Y., Luo, C., Ye, C. Reduced asymmetric dimeth …

7

Discovery and biological evaluation of vinylsulfonamide derivatives as highly potent, covalent TEAD autopalmitoylation inhibitors.

Lu W, Wang J, Li Y, Tao H, Xiong H, Lian F, Gao J, Ma H, Lu T, Zhang D, Ye X, Ding H, Yue L, Zhang Y, Tang H, Zhang N, Yang Y, Jiang H, Chen K, Zhou B, Luo C. Lu W, et al. Among authors: zhang n, zhang d, zhang y. Eur J Med Chem. 2019 Dec 15;184:111767. doi: 10.1016/j.ejmech.2019.111767. Epub 2019 Oct 9. Eur J Med Chem. 2019. PMID: 31622854

8

Covalent Inhibitors Allosterically Block the Activation of Rho Family Proteins and Suppress Cancer Cell Invasion.

Sun Z, Zhang H, Zhang Y, Liao L, Zhou W, Zhang F, Lian F, Huang J, Xu P, Zhang R, Lu W, Zhu M, Tao H, Yang F, Ding H, Chen S, Yue L, Zhou B, Zhang N, Tan M, Jiang H, Chen K, Liu B, Liu C, Dang Y, Luo C. Sun Z, et al. Among authors: zhang n, zhang r, zhang f, zhang h, zhang y. Adv Sci (Weinh). 2020 May 13;7(14):2000098. doi: 10.1002/advs.202000098. eCollection 2020 Jul. Adv Sci (Weinh). 2020. PMID: 32714746 Free PMC article.

9

PRMT1 is a novel molecular therapeutic target for clear cell renal cell carcinoma.

Wang J, Wang C, Xu P, Li X, Lu Y, Jin D, Yin X, Jiang H, Huang J, Xiong H, Ye F, Jin J, Chen Y, Xie Y, Chen Z, Ding H, Zhang H, Liu R, Jiang H, Chen K, Yao Z, Luo C, Huang Y, Zhang Y, Zhang J. Wang J, et al. Among authors: zhang j, zhang h, zhang y. Theranostics. 2021 Mar 12;11(11):5387-5403. doi: 10.7150/thno.42345. eCollection 2021. Theranostics. 2021. PMID: 33859753 Free PMC article.

10

Structure-Guided Development of Small-Molecule PRC2 Inhibitors Targeting EZH2-EED Interaction.

Du D, Xu D, Zhu L, Stazi G, Zwergel C, Liu Y, Luo Z, Li Y, Zhang Y, Zhu K, Ding Y, Liu J, Fan S, Zhao K, Zhang N, Kong X, Jiang H, Chen K, Zhao K, Valente S, Min J, Duan W, Luo C. Du D, et al. Among authors: zhang n, zhang y. J Med Chem. 2021 Jun 24;64(12):8194-8207. doi: 10.1021/acs.jmedchem.0c02261. Epub 2021 Jun 2. J Med Chem. 2021. PMID: 34077206

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