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Image-Based Morphological Profiling Identifies a Lysosomotropic, Iron-Sequestering Autophagy Inhibitor.
Laraia L, Garivet G, Foley DJ, Kaiser N, Müller S, Zinken S, Pinkert T, Wilke J, Corkery D, Pahl A, Sievers S, Janning P, Arenz C, Wu Y, Rodriguez R, Waldmann H. Laraia L, et al. Among authors: janning p. Angew Chem Int Ed Engl. 2020 Mar 27;59(14):5721-5729. doi: 10.1002/anie.201913712. Epub 2020 Jan 24. Angew Chem Int Ed Engl. 2020. PMID: 31769920 Free PMC article.
The Ras pathway modulator melophlin A targets dynamins.
Knoth T, Warburg K, Katzka C, Rai A, Wolf A, Brockmeyer A, Janning P, Reubold TF, Eschenburg S, Manstein DJ, Hübel K, Kaiser M, Waldmann H. Knoth T, et al. Among authors: janning p. Angew Chem Int Ed Engl. 2009;48(39):7240-5. doi: 10.1002/anie.200902023. Angew Chem Int Ed Engl. 2009. PMID: 19722243 No abstract available.
Identification of acyl protein thioesterases 1 and 2 as the cellular targets of the Ras-signaling modulators palmostatin B and M.
Rusch M, Zimmermann TJ, Bürger M, Dekker FJ, Görmer K, Triola G, Brockmeyer A, Janning P, Böttcher T, Sieber SA, Vetter IR, Hedberg C, Waldmann H. Rusch M, et al. Among authors: janning p. Angew Chem Int Ed Engl. 2011 Oct 10;50(42):9838-42. doi: 10.1002/anie.201102967. Epub 2011 Sep 9. Angew Chem Int Ed Engl. 2011. PMID: 21905186
Covalent-Allosteric Kinase Inhibitors.
Weisner J, Gontla R, van der Westhuizen L, Oeck S, Ketzer J, Janning P, Richters A, Mühlenberg T, Fang Z, Taher A, Jendrossek V, Pelly SC, Bauer S, van Otterlo WA, Rauh D. Weisner J, et al. Among authors: janning p. Angew Chem Int Ed Engl. 2015 Aug 24;54(35):10313-6. doi: 10.1002/anie.201502142. Epub 2015 Jun 25. Angew Chem Int Ed Engl. 2015. PMID: 26110718
Small-Molecule Target Engagement in Cells.
Schürmann M, Janning P, Ziegler S, Waldmann H. Schürmann M, et al. Among authors: janning p. Cell Chem Biol. 2016 Apr 21;23(4):435-41. doi: 10.1016/j.chembiol.2016.03.008. Epub 2016 Mar 31. Cell Chem Biol. 2016. PMID: 27049669 Free article. Review.
72 results