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Clade F AAVHSCs cross the blood brain barrier and transduce the central nervous system in addition to peripheral tissues following intravenous administration in nonhuman primates.
Ellsworth JL, Gingras J, Smith LJ, Rubin H, Seabrook TA, Patel K, Zapata N, Olivieri K, O'Callaghan M, Chlipala E, Morales P, Seymour A. Ellsworth JL, et al. Among authors: seabrook ta. PLoS One. 2019 Nov 26;14(11):e0225582. doi: 10.1371/journal.pone.0225582. eCollection 2019. PLoS One. 2019. PMID: 31770409 Free PMC article.
Single Systemic Administration of a Gene Therapy Leading to Disease Treatment in Metachromatic Leukodystrophy Arsa Knock-Out Mice.
St Martin T, Seabrook TA, Gall K, Newman J, Avila N, Hayes A, Kivaa M, Lotterhand J, Mercaldi M, Patel K, Rivas IJ, Woodcock S, Wright TL, Seymour AB, Francone OL, Gingras J. St Martin T, et al. Among authors: seabrook ta. J Neurosci. 2023 May 10;43(19):3567-3581. doi: 10.1523/JNEUROSCI.1829-22.2023. Epub 2023 Mar 28. J Neurosci. 2023. PMID: 36977578 Free PMC article.
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