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The renal hemodynamic effects of the SGLT2 inhibitor dapagliflozin are caused by post-glomerular vasodilatation rather than pre-glomerular vasoconstriction in metformin-treated patients with type 2 diabetes in the randomized, double-blind RED trial.
van Bommel EJM, Muskiet MHA, van Baar MJB, Tonneijck L, Smits MM, Emanuel AL, Bozovic A, Danser AHJ, Geurts F, Hoorn EJ, Touw DJ, Larsen EL, Poulsen HE, Kramer MHH, Nieuwdorp M, Joles JA, van Raalte DH. van Bommel EJM, et al. Among authors: emanuel al. Kidney Int. 2020 Jan;97(1):202-212. doi: 10.1016/j.kint.2019.09.013. Epub 2019 Oct 10. Kidney Int. 2020. PMID: 31791665 Free article. Clinical Trial.
Iloprost infusion prevents the insulin-induced reduction in skeletal muscle microvascular blood volume but does not enhance peripheral glucose uptake in type 2 diabetic patients.
Emanuel AL, de Clercq NC, Koopen AM, van Poelgeest E, Serlie MJM, van Raalte DH, Kramer MHH, Nieuwdorp M, Eringa EC, Serné EH. Emanuel AL, et al. Diabetes Obes Metab. 2018 Nov;20(11):2523-2531. doi: 10.1111/dom.13410. Epub 2018 Jul 27. Diabetes Obes Metab. 2018. PMID: 29885045 Clinical Trial.
The presence of cerebral white matter lesions and lower skin microvascular perfusion predicts lower cognitive performance in type 1 diabetes patients with retinopathy but not in healthy controls-A longitudinal study.
Emanuel AL, van Duinkerken E, Wattjes MP, Klein M, Barkhof F, Snoek FJ, Diamant M, Eringa EC, IJzerman RG, Serné EH. Emanuel AL, et al. Microcirculation. 2019 Apr;26(3):e12530. doi: 10.1111/micc.12530. Epub 2019 Feb 22. Microcirculation. 2019. PMID: 30659710 Free PMC article. Clinical Trial.
[How to manage acute urine retention?].
Emanuel AL, Stoots S, Joosten EAHM. Emanuel AL, et al. Ned Tijdschr Geneeskd. 2021 Jun 7;165:D5817. Ned Tijdschr Geneeskd. 2021. PMID: 34346624 Dutch.