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A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity.
Khan S, Zhang X, Lv D, Zhang Q, He Y, Zhang P, Liu X, Thummuri D, Yuan Y, Wiegand JS, Pei J, Zhang W, Sharma A, McCurdy CR, Kuruvilla VM, Baran N, Ferrando AA, Kim YM, Rogojina A, Houghton PJ, Huang G, Hromas R, Konopleva M, Zheng G, Zhou D. Khan S, et al. Among authors: sharma a. Nat Med. 2019 Dec;25(12):1938-1947. doi: 10.1038/s41591-019-0668-z. Epub 2019 Dec 2. Nat Med. 2019. PMID: 31792461 Free PMC article.
Bioanalytical method development and validation of MES207, a neuropeptide FF receptor antagonist, and its application in preclinical pharmacokinetics.
King TI, Roewekamp AC, Sharma A, Harrison S, Mesangeau C, Mottinelli M, Kamble SH, McCurdy CR, Avery BA. King TI, et al. Among authors: sharma a. J Chromatogr B Analyt Technol Biomed Life Sci. 2019 Dec 15;1134-1135:121875. doi: 10.1016/j.jchromb.2019.121875. Epub 2019 Nov 12. J Chromatogr B Analyt Technol Biomed Life Sci. 2019. PMID: 31790916 Free PMC article.
Investigation of the Adrenergic and Opioid Binding Affinities, Metabolic Stability, Plasma Protein Binding Properties, and Functional Effects of Selected Indole-Based Kratom Alkaloids.
Obeng S, Kamble SH, Reeves ME, Restrepo LF, Patel A, Behnke M, Chear NJ, Ramanathan S, Sharma A, León F, Hiranita T, Avery BA, McMahon LR, McCurdy CR. Obeng S, et al. Among authors: sharma a. J Med Chem. 2020 Jan 9;63(1):433-439. doi: 10.1021/acs.jmedchem.9b01465. Epub 2019 Dec 27. J Med Chem. 2020. PMID: 31834797 Free PMC article.
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