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Pyrazolones Activate the Proteasome by Gating Mechanisms and Protect Neuronal Cells from β-Amyloid Toxicity.
Santoro AM, Lanza V, Bellia F, Sbardella D, Tundo GR, Cannizzo A, Grasso G, Arizzi M, Nicoletti VG, Alcaro S, Costa G, Pietropaolo A, Malgieri G, D'Abrosca G, Fattorusso R, García-Viñuales S, Ahmed IMM, Coletta M, Milardi D. Santoro AM, et al. ChemMedChem. 2020 Feb 5;15(3):302-316. doi: 10.1002/cmdc.201900612. Epub 2019 Dec 17. ChemMedChem. 2020. PMID: 31797568
Carnosine interaction with nitric oxide and astroglial cell protection.
Nicoletti VG, Santoro AM, Grasso G, Vagliasindi LI, Giuffrida ML, Cuppari C, Purrello VS, Stella AM, Rizzarelli E. Nicoletti VG, et al. Among authors: santoro am. J Neurosci Res. 2007 Aug 1;85(10):2239-45. doi: 10.1002/jnr.21365. J Neurosci Res. 2007. PMID: 17546663
Cationic porphyrins are reversible proteasome inhibitors.
Santoro AM, Lo Giudice MC, D'Urso A, Lauceri R, Purrello R, Milardi D. Santoro AM, et al. J Am Chem Soc. 2012 Jun 27;134(25):10451-7. doi: 10.1021/ja300781u. Epub 2012 Jun 6. J Am Chem Soc. 2012. PMID: 22642538 Free article.
Electrostatic Map Of Proteasome α-Rings Encodes The Design of Allosteric Porphyrin-Based Inhibitors Able To Affect 20S Conformation By Cooperative Binding.
Dato AD, Cunsolo A, Persico M, Santoro AM, D'Urso A, Milardi D, Purrello R, Stefanelli M, Paolesse R, Tundo GR, Sbardella D, Fattorusso C, Coletta M. Dato AD, et al. Among authors: santoro am. Sci Rep. 2017 Dec 6;7(1):17098. doi: 10.1038/s41598-017-17008-7. Sci Rep. 2017. PMID: 29213119 Free PMC article.
The insulin-degrading enzyme is an allosteric modulator of the 20S proteasome and a potential competitor of the 19S.
Sbardella D, Tundo GR, Coletta A, Marcoux J, Koufogeorgou EI, Ciaccio C, Santoro AM, Milardi D, Grasso G, Cozza P, Bousquet-Dubouch MP, Marini S, Coletta M. Sbardella D, et al. Among authors: santoro am. Cell Mol Life Sci. 2018 Sep;75(18):3441-3456. doi: 10.1007/s00018-018-2807-y. Epub 2018 Mar 28. Cell Mol Life Sci. 2018. PMID: 29594388 Free PMC article.
Cationic porphyrins are tunable gatekeepers of the 20S proteasome.
Santoro AM, Cunsolo A, D'Urso A, Sbardella D, Tundo GR, Ciaccio C, Coletta M, Diana D, Fattorusso R, Persico M, Di Dato A, Fattorusso C, Milardi D, Purrello R. Santoro AM, et al. Chem Sci. 2016 Feb 1;7(2):1286-1297. doi: 10.1039/c5sc03312h. Epub 2015 Nov 9. Chem Sci. 2016. PMID: 29910886 Free PMC article.
Defective proteasome biogenesis into skin fibroblasts isolated from Rett syndrome subjects with MeCP2 non-sense mutations.
Sbardella D, Tundo GR, Cunsolo V, Grasso G, Cascella R, Caputo V, Santoro AM, Milardi D, Pecorelli A, Ciaccio C, Di Pierro D, Leoncini S, Campagnolo L, Pironi V, Oddone F, Manni P, Foti S, Giardina E, De Felice C, Hayek J, Curatolo P, Galasso C, Valacchi G, Coletta M, Graziani G, Marini S. Sbardella D, et al. Among authors: santoro am. Biochim Biophys Acta Mol Basis Dis. 2020 Jul 1;1866(7):165793. doi: 10.1016/j.bbadis.2020.165793. Epub 2020 Apr 8. Biochim Biophys Acta Mol Basis Dis. 2020. PMID: 32275946 Free article.
The Ionophoric Activity of a Pro-Apoptotic VEGF165 Fragment on HUVEC Cells.
Zimbone S, Santoro AM, La Mendola D, Giacomelli C, Trincavelli ML, Tomasello MF, Milardi D, García-Viñuales S, Sciacca MFM, Martini C, Grasso G. Zimbone S, et al. Among authors: santoro am. Int J Mol Sci. 2020 Apr 20;21(8):2866. doi: 10.3390/ijms21082866. Int J Mol Sci. 2020. PMID: 32325956 Free PMC article.
50 results