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HAS3-induced extracellular vesicles from melanoma cells stimulate IHH mediated c-Myc upregulation via the hedgehog signaling pathway in target cells.
Arasu UT, Deen AJ, Pasonen-Seppänen S, Heikkinen S, Lalowski M, Kärnä R, Härkönen K, Mäkinen P, Lázaro-Ibáñez E, Siljander PR, Oikari S, Levonen AL, Rilla K. Arasu UT, et al. Among authors: deen aj. Cell Mol Life Sci. 2020 Oct;77(20):4093-4115. doi: 10.1007/s00018-019-03399-5. Epub 2019 Dec 9. Cell Mol Life Sci. 2020. PMID: 31820036 Free PMC article.
Hyaluronan production enhances shedding of plasma membrane-derived microvesicles.
Rilla K, Pasonen-Seppänen S, Deen AJ, Koistinen VVT, Wojciechowski S, Oikari S, Kärnä R, Bart G, Törrönen K, Tammi RH, Tammi MI. Rilla K, et al. Among authors: deen aj. Exp Cell Res. 2013 Aug 1;319(13):2006-2018. doi: 10.1016/j.yexcr.2013.05.021. Epub 2013 Jun 1. Exp Cell Res. 2013. PMID: 23732660
Regulation of stress signaling pathways by nitro-fatty acids.
Deen AJ, Sihvola V, Härkönen J, Patinen T, Adinolfi S, Levonen AL. Deen AJ, et al. Nitric Oxide. 2018 Mar 19:S1089-8603(17)30323-3. doi: 10.1016/j.niox.2018.03.012. Online ahead of print. Nitric Oxide. 2018. PMID: 29567143 Review.
The calcium-activated chloride channel-associated protein rCLCA2 is expressed throughout rat epidermis, facilitates apoptosis and is downmodulated by UVB.
Hämäläinen L, Bart G, Takabe P, Rauhala L, Deen A, Pasonen-Seppänen S, Kärkkäinen E, Kärnä R, Kumlin T, Tammi MI, Tammi RH. Hämäläinen L, et al. Histochem Cell Biol. 2021 May;155(5):605-615. doi: 10.1007/s00418-021-01962-5. Epub 2021 Jan 23. Histochem Cell Biol. 2021. PMID: 33486586 Free PMC article.
A pan-cancer analysis shows immunoevasive characteristics in NRF2 hyperactive squamous malignancies.
Härkönen J, Pölönen P, Deen AJ, Selvarajan I, Teppo HR, Dimova EY, Kietzmann T, Ahtiainen M, Väyrynen JP, Väyrynen SA, Elomaa H, Tynkkynen N, Eklund T, Kuopio T, Talvitie EM, Taimen P, Kallajoki M, Kaikkonen MU, Heinäniemi M, Levonen AL. Härkönen J, et al. Among authors: deen aj. Redox Biol. 2023 May;61:102644. doi: 10.1016/j.redox.2023.102644. Epub 2023 Feb 27. Redox Biol. 2023. PMID: 36867945 Free PMC article.
Oncogenic KEAP1 mutations activate TRAF2-NFκB signaling to prevent apoptosis in lung cancer cells.
Deen AJ, Adinolfi S, Härkönen J, Patinen T, Liu X, Laitinen T, Takabe P, Kainulainen K, Pasonen-Seppänen S, Gawriyski LM, Arasu UT, Selvarajan I, Mäkinen P, Laitinen H, Kansanen E, Kaikkonen MU, Poso A, Varjosalo M, Levonen AL. Deen AJ, et al. Redox Biol. 2024 Feb;69:103031. doi: 10.1016/j.redox.2024.103031. Epub 2024 Jan 4. Redox Biol. 2024. PMID: 38184997 Free PMC article.
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