Kärnä R - Search Results

1

HAS3-induced extracellular vesicles from melanoma cells stimulate IHH mediated c-Myc upregulation via the hedgehog signaling pathway in target cells.

Arasu UT, Deen AJ, Pasonen-Seppänen S, Heikkinen S, Lalowski M, Kärnä R, Härkönen K, Mäkinen P, Lázaro-Ibáñez E, Siljander PR, Oikari S, Levonen AL, Rilla K. Arasu UT, et al. Among authors: karna r. Cell Mol Life Sci. 2020 Oct;77(20):4093-4115. doi: 10.1007/s00018-019-03399-5. Epub 2019 Dec 9. Cell Mol Life Sci. 2020. PMID: 31820036 Free PMC article.

2

UDP-sugar substrates of HAS3 regulate its O-GlcNAcylation, intracellular traffic, extracellular shedding and correlate with melanoma progression.

Deen AJ, Arasu UT, Pasonen-Seppänen S, Hassinen A, Takabe P, Wojciechowski S, Kärnä R, Rilla K, Kellokumpu S, Tammi R, Tammi M, Oikari S. Deen AJ, et al. Among authors: karna r. Cell Mol Life Sci. 2016 Aug;73(16):3183-204. doi: 10.1007/s00018-016-2158-5. Epub 2016 Feb 16. Cell Mol Life Sci. 2016. PMID: 26883802 Free PMC article.

3

EMT induced by EGF and wounding activates hyaluronan synthesis machinery and EV shedding in rat primary mesothelial cells.

Koistinen V, Härkönen K, Kärnä R, Arasu UT, Oikari S, Rilla K. Koistinen V, et al. Among authors: karna r. Matrix Biol. 2017 Nov;63:38-54. doi: 10.1016/j.matbio.2016.12.007. Epub 2016 Dec 30. Matrix Biol. 2017. PMID: 28043889

4

Human mesenchymal stem cells secrete hyaluronan-coated extracellular vesicles.

Arasu UT, Kärnä R, Härkönen K, Oikari S, Koistinen A, Kröger H, Qu C, Lammi MJ, Rilla K. Arasu UT, et al. Among authors: karna r. Matrix Biol. 2017 Dec;64:54-68. doi: 10.1016/j.matbio.2017.05.001. Epub 2017 May 5. Matrix Biol. 2017. PMID: 28483644

5

Effects of mutations in the post-translational modification sites on the trafficking of hyaluronan synthase 2 (HAS2).

Melero-Fernandez de Mera RM, Arasu UT, Kärnä R, Oikari S, Rilla K, Vigetti D, Passi A, Heldin P, Tammi MI, Deen AJ. Melero-Fernandez de Mera RM, et al. Among authors: karna r. Matrix Biol. 2019 Jul;80:85-103. doi: 10.1016/j.matbio.2018.10.004. Epub 2018 Oct 27. Matrix Biol. 2019. PMID: 30394292

6

4-Methylumbelliferone inhibits hyaluronan synthesis by depletion of cellular UDP-glucuronic acid and downregulation of hyaluronan synthase 2 and 3.

Kultti A, Pasonen-Seppänen S, Jauhiainen M, Rilla KJ, Kärnä R, Pyöriä E, Tammi RH, Tammi MI. Kultti A, et al. Among authors: karna r. Exp Cell Res. 2009 Jul 1;315(11):1914-23. doi: 10.1016/j.yexcr.2009.03.002. Epub 2009 Mar 13. Exp Cell Res. 2009. PMID: 19285976

7

HAS3-induced accumulation of hyaluronan in 3D MDCK cultures results in mitotic spindle misorientation and disturbed organization of epithelium.

Rilla K, Pasonen-Seppänen S, Kärnä R, Karjalainen HM, Törrönen K, Koistinen V, Tammi MI, Tammi RH, Teräväinen T, Manninen A. Rilla K, et al. Among authors: karna r. Histochem Cell Biol. 2012 Feb;137(2):153-64. doi: 10.1007/s00418-011-0896-x. Epub 2011 Dec 8. Histochem Cell Biol. 2012. PMID: 22159845

8

Hyaluronan synthase 1 (HAS1) requires higher cellular UDP-GlcNAc concentration than HAS2 and HAS3.

Rilla K, Oikari S, Jokela TA, Hyttinen JM, Kärnä R, Tammi RH, Tammi MI. Rilla K, et al. Among authors: karna r. J Biol Chem. 2013 Feb 22;288(8):5973-83. doi: 10.1074/jbc.M112.443879. Epub 2013 Jan 9. J Biol Chem. 2013. PMID: 23303191 Free PMC article.

9

Hyaluronan production enhances shedding of plasma membrane-derived microvesicles.

Rilla K, Pasonen-Seppänen S, Deen AJ, Koistinen VVT, Wojciechowski S, Oikari S, Kärnä R, Bart G, Törrönen K, Tammi RH, Tammi MI. Rilla K, et al. Among authors: karna r. Exp Cell Res. 2013 Aug 1;319(13):2006-2018. doi: 10.1016/j.yexcr.2013.05.021. Epub 2013 Jun 1. Exp Cell Res. 2013. PMID: 23732660

10

Rab10-mediated endocytosis of the hyaluronan synthase HAS3 regulates hyaluronan synthesis and cell adhesion to collagen.

Deen AJ, Rilla K, Oikari S, Kärnä R, Bart G, Häyrinen J, Bathina AR, Ropponen A, Makkonen K, Tammi RH, Tammi MI. Deen AJ, et al. Among authors: karna r. J Biol Chem. 2014 Mar 21;289(12):8375-89. doi: 10.1074/jbc.M114.552133. Epub 2014 Feb 7. J Biol Chem. 2014. PMID: 24509846 Free PMC article.

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