Hoffmann RM - Search Results

1

Characterization of the c10orf76-PI4KB complex and its necessity for Golgi PI4P levels and enterovirus replication.

McPhail JA, Lyoo H, Pemberton JG, Hoffmann RM, van Elst W, Strating JRPM, Jenkins ML, Stariha JTB, Powell CJ, Boulanger MJ, Balla T, van Kuppeveld FJM, Burke JE. McPhail JA, et al. Among authors: hoffmann rm. EMBO Rep. 2020 Feb 5;21(2):e48441. doi: 10.15252/embr.201948441. Epub 2019 Dec 12. EMBO Rep. 2020. PMID: 31829496 Free PMC article.

2

Probing Protein-Membrane Interactions and Dynamics Using Hydrogen-Deuterium Exchange Mass Spectrometry (HDX-MS).

Stariha JTB, Hoffmann RM, Hamelin DJ, Burke JE. Stariha JTB, et al. Among authors: hoffmann rm. Methods Mol Biol. 2021;2263:465-485. doi: 10.1007/978-1-0716-1197-5_22. Methods Mol Biol. 2021. PMID: 33877613

3

Structural determinants of Rab11 activation by the guanine nucleotide exchange factor SH3BP5.

Jenkins ML, Margaria JP, Stariha JTB, Hoffmann RM, McPhail JA, Hamelin DJ, Boulanger MJ, Hirsch E, Burke JE. Jenkins ML, et al. Among authors: hoffmann rm. Nat Commun. 2018 Sep 14;9(1):3772. doi: 10.1038/s41467-018-06196-z. Nat Commun. 2018. PMID: 30217979 Free PMC article.

4

Dynamics of allosteric regulation of the phospholipase C-γ isozymes upon recruitment to membranes.

Siraliev-Perez E, Stariha JTB, Hoffmann RM, Temple BRS, Zhang Q, Hajicek N, Jenkins ML, Burke JE, Sondek J. Siraliev-Perez E, et al. Among authors: hoffmann rm. Elife. 2022 Jun 16;11:e77809. doi: 10.7554/eLife.77809. Elife. 2022. PMID: 35708309 Free PMC article.

5

Probing the Architecture, Dynamics, and Inhibition of the PI4KIIIα/TTC7/FAM126 Complex.

Dornan GL, Dalwadi U, Hamelin DJ, Hoffmann RM, Yip CK, Burke JE. Dornan GL, et al. Among authors: hoffmann rm. J Mol Biol. 2018 Sep 14;430(18 Pt B):3129-3142. doi: 10.1016/j.jmb.2018.07.020. Epub 2018 Jul 18. J Mol Biol. 2018. PMID: 30031006

6

The middle lipin domain adopts a membrane-binding dimeric protein fold.

Gu W, Gao S, Wang H, Fleming KD, Hoffmann RM, Yang JW, Patel NM, Choi YM, Burke JE, Reue K, Airola MV. Gu W, et al. Among authors: hoffmann rm. Nat Commun. 2021 Aug 5;12(1):4718. doi: 10.1038/s41467-021-24929-5. Nat Commun. 2021. PMID: 34354069 Free PMC article.

7

The juxtamembrane linker in neutral sphingomyelinase-2 functions as an intramolecular allosteric switch that activates the enzyme.

Shanbhogue P, Hoffmann RM, Airola MV, Maini R, Hamelin DJ, Garcia-Diaz M, Burke JE, Hannun YA. Shanbhogue P, et al. Among authors: hoffmann rm. J Biol Chem. 2019 May 3;294(18):7488-7502. doi: 10.1074/jbc.RA118.007288. Epub 2019 Mar 19. J Biol Chem. 2019. PMID: 30890560 Free PMC article.

8

(S)-4-(Difluoromethyl)-5-(4-(3-methylmorpholino)-6-morpholino-1,3,5-triazin-2-yl)pyridin-2-amine (PQR530), a Potent, Orally Bioavailable, and Brain-Penetrable Dual Inhibitor of Class I PI3K and mTOR Kinase.

Rageot D, Bohnacker T, Keles E, McPhail JA, Hoffmann RM, Melone A, Borsari C, Sriramaratnam R, Sele AM, Beaufils F, Hebeisen P, Fabbro D, Hillmann P, Burke JE, Wymann MP. Rageot D, et al. Among authors: hoffmann rm. J Med Chem. 2019 Jul 11;62(13):6241-6261. doi: 10.1021/acs.jmedchem.9b00525. Epub 2019 Jun 20. J Med Chem. 2019. PMID: 31244112 Free article.

9

Crystal structure of a lipin/Pah phosphatidic acid phosphatase.

Khayyo VI, Hoffmann RM, Wang H, Bell JA, Burke JE, Reue K, Airola MV. Khayyo VI, et al. Among authors: hoffmann rm. Nat Commun. 2020 Mar 11;11(1):1309. doi: 10.1038/s41467-020-15124-z. Nat Commun. 2020. PMID: 32161260 Free PMC article.

10

Integrated Structural Modeling of Full-Length LRH-1 Reveals Inter-domain Interactions Contribute to Receptor Structure and Function.

Seacrist CD, Kuenze G, Hoffmann RM, Moeller BE, Burke JE, Meiler J, Blind RD. Seacrist CD, et al. Among authors: hoffmann rm. Structure. 2020 Jul 7;28(7):830-846.e9. doi: 10.1016/j.str.2020.04.020. Epub 2020 May 19. Structure. 2020. PMID: 32433991 Free PMC article.

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