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Phase II study of tailored chemotherapy for advanced colorectal cancer with either 5-fluouracil and leucovorin or oxaliplatin and irinotecan based on the expression of thymidylate synthase and dihydropyrimidine dehydrogenase.
Smorenburg CH, Peters GJ, van Groeningen CJ, Noordhuis P, Smid K, van Riel AM, Dercksen W, Pinedo HM, Giaccone G. Smorenburg CH, et al. Ann Oncol. 2006 Jan;17(1):35-42. doi: 10.1093/annonc/mdj046. Epub 2005 Oct 26. Ann Oncol. 2006. PMID: 16251201 Free article. Clinical Trial.