O'Keefe BR - Search Results

1

Targeting Protein Translation by Rocaglamide and Didesmethylrocaglamide to Treat MPNST and Other Sarcomas.

Chang LS, Oblinger JL, Burns SS, Huang J, Anderson LW, Hollingshead MG, Shen R, Pan L, Agarwal G, Ren Y, Roberts RD, O'Keefe BR, Kinghorn AD, Collins JM. Chang LS, et al. Mol Cancer Ther. 2020 Mar;19(3):731-741. doi: 10.1158/1535-7163.MCT-19-0809. Epub 2019 Dec 17. Mol Cancer Ther. 2020. PMID: 31848295 Free PMC article.

2

Erythrofordins D and E, two new cassaine-type diterpenes from Erythrophleum suaveolens.

Grkovic T, Evans JR, Akee RK, Guo L, Davis M, Jato J, Grothaus PG, Ahalt-Gottholm M, Hollingshead M, Collins JM, Newman DJ, O'Keefe BR. Grkovic T, et al. Bioorg Med Chem Lett. 2019 Jan 15;29(2):134-137. doi: 10.1016/j.bmcl.2018.12.019. Epub 2018 Dec 10. Bioorg Med Chem Lett. 2019. PMID: 30553734 Free PMC article.

3

Molecular genomic features associated with in vitro response of the NCI-60 cancer cell line panel to natural products.

Krushkal J, Negi S, Yee LM, Evans JR, Grkovic T, Palmisano A, Fang J, Sankaran H, McShane LM, Zhao Y, O'Keefe BR. Krushkal J, et al. Mol Oncol. 2021 Feb;15(2):381-406. doi: 10.1002/1878-0261.12849. Epub 2020 Nov 24. Mol Oncol. 2021. PMID: 33169510 Free PMC article.

4

Antiproliferative Alkaloids from Alangium longiflorum, an Endangered Tropical Plant Species.

Takeuchi M, Saito Y, Goto M, Miyake K, Newman DJ, O'Keefe BR, Lee KH, Nakagawa-Goto K. Takeuchi M, et al. J Nat Prod. 2018 Aug 24;81(8):1884-1891. doi: 10.1021/acs.jnatprod.8b00411. Epub 2018 Aug 14. J Nat Prod. 2018. PMID: 30106296 Free PMC article.

5

Anacolosins A-F and Corymbulosins X and Y, Clerodane Diterpenes from Anacolosa clarkii Exhibiting Cytotoxicity toward Pediatric Cancer Cell Lines.

Cai S, Risinger AL, Petersen CL, Grkovic T, O'Keefe BR, Mooberry SL, Cichewicz RH. Cai S, et al. J Nat Prod. 2019 Apr 26;82(4):928-936. doi: 10.1021/acs.jnatprod.8b01015. Epub 2019 Mar 4. J Nat Prod. 2019. PMID: 30830773 Free PMC article.

6

Isolation, Structure Elucidation, and Antiproliferative Activity of Butanolides and Lignan Glycosides from the Fruit of Hernandia nymphaeifolia.

Aimaiti S, Saito Y, Fukuyoshi S, Goto M, Miyake K, Newman DJ, O'Keefe BR, Lee KH, Nakagawa-Goto K. Aimaiti S, et al. Molecules. 2019 Nov 5;24(21):4005. doi: 10.3390/molecules24214005. Molecules. 2019. PMID: 31694283 Free PMC article.

7

CRISPR-Cas9 Genome-Wide Knockout Screen Identifies Mechanism of Selective Activity of Dehydrofalcarinol in Mesenchymal Stem-like Triple-Negative Breast Cancer Cells.

Grant CV, Cai S, Risinger AL, Liang H, O'Keefe BR, Doench JG, Cichewicz RH, Mooberry SL. Grant CV, et al. J Nat Prod. 2020 Oct 23;83(10):3080-3092. doi: 10.1021/acs.jnatprod.0c00642. Epub 2020 Oct 6. J Nat Prod. 2020. PMID: 33021790 Free PMC article.

8

Identification of inhibitors for MDM2 ubiquitin ligase activity from natural product extracts by a novel high-throughput electrochemiluminescent screen.

Sasiela CA, Stewart DH, Kitagaki J, Safiran YJ, Yang Y, Weissman AM, Oberoi P, Davydov IV, Goncharova E, Beutler JA, McMahon JB, O'Keefe BR. Sasiela CA, et al. J Biomol Screen. 2008 Mar;13(3):229-37. doi: 10.1177/1087057108315038. Epub 2008 Feb 12. J Biomol Screen. 2008. PMID: 18270365

9

NCI Program for Natural Product Discovery: A Publicly-Accessible Library of Natural Product Fractions for High-Throughput Screening.

Thornburg CC, Britt JR, Evans JR, Akee RK, Whitt JA, Trinh SK, Harris MJ, Thompson JR, Ewing TL, Shipley SM, Grothaus PG, Newman DJ, Schneider JP, Grkovic T, O'Keefe BR. Thornburg CC, et al. ACS Chem Biol. 2018 Sep 21;13(9):2484-2497. doi: 10.1021/acschembio.8b00389. Epub 2018 Jun 13. ACS Chem Biol. 2018. PMID: 29812901 Free PMC article.

10

Using the Cancer Dependency Map to Identify the Mechanism of Action of a Cytotoxic Alkenyl Derivative from the Fruit of Choerospondias axillaris.

Kil YS, Risinger AL, Petersen CL, Liang H, Grkovic T, O'Keefe BR, Mooberry SL, Cichewicz RH. Kil YS, et al. J Nat Prod. 2020 Mar 27;83(3):584-592. doi: 10.1021/acs.jnatprod.9b00896. Epub 2020 Feb 27. J Nat Prod. 2020. PMID: 32105068 Free PMC article.

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