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Epistane, an anabolic steroid used for recreational purposes, causes cholestasis with elevated levels of cholic acid conjugates, by upregulating bile acid synthesis (CYP8B1) and cross-talking with nuclear receptors in human hepatocytes.
Petrov PD, Fernández-Murga L, Conde I, Martínez-Sena T, Guzmán C, Castell JV, Jover R. Petrov PD, et al. Among authors: martinez sena t. Arch Toxicol. 2020 Feb;94(2):589-607. doi: 10.1007/s00204-019-02643-y. Epub 2020 Jan 1. Arch Toxicol. 2020. PMID: 31894354
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