Cohen L - Search Results

1

Biotransformation Pathways and Metabolite Profiles of Oral [¹⁴C]Alisertib (MLN8237), an Investigational Aurora A Kinase Inhibitor, in Patients with Advanced Solid Tumors.

Pusalkar S, Zhou X, Li Y, Cohen L, Yang JJ, Balani SK, Xia C, Shyu WC, Lu C, Venkatakrishnan K, Chowdhury SK. Pusalkar S, et al. Among authors: cohen l. Drug Metab Dispos. 2020 Mar;48(3):217-229. doi: 10.1124/dmd.119.087338. Epub 2020 Jan 7. Drug Metab Dispos. 2020. PMID: 31911485 Free PMC article.

2

Emerging in vitro tools to evaluate cytochrome P450 and transporter-mediated drug-drug interactions.

Lu C, Liao M, Cohen L, Xia CQ. Lu C, et al. Among authors: cohen l. Curr Drug Discov Technol. 2010 Sep;7(3):199-222. doi: 10.2174/157016310793180549. Curr Drug Discov Technol. 2010. PMID: 20843292 Review.

3

Mechanistic evaluation of substrate inhibition kinetics observed from aldehyde oxidase-catalyzed reactions.

Wang SW, Abdul-Hadi K, Cohen L, Xia CQ. Wang SW, et al. Among authors: cohen l. Drug Metab Lett. 2013 Mar;7(1):2-14. doi: 10.2174/18723128112066660017. Drug Metab Lett. 2013. PMID: 24151826

4

Metabolism and Disposition of [¹⁴C]Pevonedistat, a First-in-Class NEDD8-Activating Enzyme Inhibitor, after Intravenous Infusion to Patients with Advanced Solid Tumors.

Bolleddula J, Chen H, Cohen L, Zhou X, Pusalkar S, Berger A, Sedarati F, Venkatakrishnan K, Chowdhury SK. Bolleddula J, et al. Among authors: cohen l. Drug Metab Dispos. 2022 Jul;50(7):989-997. doi: 10.1124/dmd.122.000842. Epub 2022 May 3. Drug Metab Dispos. 2022. PMID: 35504658

5

Sinusoidal Uptake Determines the Hepatic Clearance of Pevonedistat (TAK-924) as Explained by Extended Clearance Model.

Sandoval P, Chuang BC, Cohen L, Yoneyama T, Pusalkar S, Yucha RW, Chowdhury SK, Chothe PP. Sandoval P, et al. Among authors: cohen l. Drug Metab Dispos. 2022 Jul;50(7):980-988. doi: 10.1124/dmd.122.000836. Epub 2022 May 11. Drug Metab Dispos. 2022. PMID: 35545257

6

Metabolism and Excretion of [¹⁴C]Mobocertinib, a Selective Covalent Inhibitor of Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertion Mutations, in Healthy Male Subjects.

Chen H, Shah A, Kato S, Griffin R, Zhang S, Pusalkar S, Cohen L, Li Y, Chowdhury SK, Zhu SX. Chen H, et al. Among authors: cohen l. Drug Metab Dispos. 2024 Sep 16;52(10):1115-1123. doi: 10.1124/dmd.124.001841. Drug Metab Dispos. 2024. PMID: 39038951

7

Discovery of TAK-981, a First-in-Class Inhibitor of SUMO-Activating Enzyme for the Treatment of Cancer.

Langston SP, Grossman S, England D, Afroze R, Bence N, Bowman D, Bump N, Chau R, Chuang BC, Claiborne C, Cohen L, Connolly K, Duffey M, Durvasula N, Freeze S, Gallery M, Galvin K, Gaulin J, Gershman R, Greenspan P, Grieves J, Guo J, Gulavita N, Hailu S, He X, Hoar K, Hu Y, Hu Z, Ito M, Kim MS, Lane SW, Lok D, Lublinsky A, Mallender W, McIntyre C, Minissale J, Mizutani H, Mizutani M, Molchinova N, Ono K, Patil A, Qian M, Riceberg J, Shindi V, Sintchak MD, Song K, Soucy T, Wang Y, Xu H, Yang X, Zawadzka A, Zhang J, Pulukuri SM. Langston SP, et al. Among authors: cohen l. J Med Chem. 2021 Mar 11;64(5):2501-2520. doi: 10.1021/acs.jmedchem.0c01491. Epub 2021 Feb 25. J Med Chem. 2021. PMID: 33631934 Free article.

8

In vitro drug interactions of cytochrome p450: an evaluation of fluorogenic to conventional substrates.

Cohen LH, Remley MJ, Raunig D, Vaz AD. Cohen LH, et al. Drug Metab Dispos. 2003 Aug;31(8):1005-15. doi: 10.1124/dmd.31.8.1005. Drug Metab Dispos. 2003. PMID: 12867489

9

Radiosynthesis and Early Evaluation of a Positron Emission Tomography Imaging Probe [¹⁸F]AGAL Targeting Alpha-Galactosidase A Enzyme for Fabry Disease.

Lohith TG, Kaittanis C, Belanger AP, Ahn SH, Sandoval P, Cohen L, Rajarshi G, Ruangsiriluk W, Islam R, Winkelmann CT, McQuade P. Lohith TG, et al. Among authors: cohen l. Molecules. 2023 Oct 18;28(20):7144. doi: 10.3390/molecules28207144. Molecules. 2023. PMID: 37894622 Free PMC article.

10

Exoscopic Repair of Orbital Meningoencephalocele Causing Pulsatile Proptosis: A 2-Dimensional Operative Video.

Nandoliya KR, Sadagopan NS, Karras CL, Cohen LM, Magill ST. Nandoliya KR, et al. Among authors: cohen lm. Oper Neurosurg (Hagerstown). 2024 Dec 16. doi: 10.1227/ons.0000000000001470. Online ahead of print. Oper Neurosurg (Hagerstown). 2024. PMID: 39681332 No abstract available.

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