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The epichaperome is a mediator of toxic hippocampal stress and leads to protein connectivity-based dysfunction.
Inda MC, Joshi S, Wang T, Bolaender A, Gandu S, Koren Iii J, Che AY, Taldone T, Yan P, Sun W, Uddin M, Panchal P, Riolo M, Shah S, Barlas A, Xu K, Chan LYL, Gruzinova A, Kishinevsky S, Studer L, Fossati V, Noggle SA, White JR, de Stanchina E, Sequeira S, Anthoney KH, Steele JW, Manova-Todorova K, Patil S, Dunphy MP, Pillarsetty N, Pereira AC, Erdjument-Bromage H, Neubert TA, Rodina A, Ginsberg SD, De Marco Garcia N, Luo W, Chiosis G. Inda MC, et al. Among authors: studer l. Nat Commun. 2020 Jan 16;11(1):319. doi: 10.1038/s41467-019-14082-5. Nat Commun. 2020. PMID: 31949159 Free PMC article.
A poised chromatin platform for TGF-β access to master regulators.
Xi Q, Wang Z, Zaromytidou AI, Zhang XH, Chow-Tsang LF, Liu JX, Kim H, Barlas A, Manova-Todorova K, Kaartinen V, Studer L, Mark W, Patel DJ, Massagué J. Xi Q, et al. Among authors: studer l. Cell. 2011 Dec 23;147(7):1511-24. doi: 10.1016/j.cell.2011.11.032. Cell. 2011. PMID: 22196728 Free PMC article.
Human iPSC-based modeling of late-onset disease via progerin-induced aging.
Miller JD, Ganat YM, Kishinevsky S, Bowman RL, Liu B, Tu EY, Mandal PK, Vera E, Shim JW, Kriks S, Taldone T, Fusaki N, Tomishima MJ, Krainc D, Milner TA, Rossi DJ, Studer L. Miller JD, et al. Among authors: studer l. Cell Stem Cell. 2013 Dec 5;13(6):691-705. doi: 10.1016/j.stem.2013.11.006. Cell Stem Cell. 2013. PMID: 24315443 Free PMC article.
Deriving human ENS lineages for cell therapy and drug discovery in Hirschsprung disease.
Fattahi F, Steinbeck JA, Kriks S, Tchieu J, Zimmer B, Kishinevsky S, Zeltner N, Mica Y, El-Nachef W, Zhao H, de Stanchina E, Gershon MD, Grikscheit TC, Chen S, Studer L. Fattahi F, et al. Among authors: studer l. Nature. 2016 Mar 3;531(7592):105-9. doi: 10.1038/nature16951. Epub 2016 Feb 10. Nature. 2016. PMID: 26863197 Free PMC article.
Parkin and PINK1 Patient iPSC-Derived Midbrain Dopamine Neurons Exhibit Mitochondrial Dysfunction and α-Synuclein Accumulation.
Chung SY, Kishinevsky S, Mazzulli JR, Graziotto J, Mrejeru A, Mosharov EV, Puspita L, Valiulahi P, Sulzer D, Milner TA, Taldone T, Krainc D, Studer L, Shim JW. Chung SY, et al. Among authors: studer l. Stem Cell Reports. 2016 Oct 11;7(4):664-677. doi: 10.1016/j.stemcr.2016.08.012. Epub 2016 Sep 15. Stem Cell Reports. 2016. PMID: 27641647 Free PMC article.
The epichaperome is an integrated chaperome network that facilitates tumour survival.
Rodina A, Wang T, Yan P, Gomes ED, Dunphy MP, Pillarsetty N, Koren J, Gerecitano JF, Taldone T, Zong H, Caldas-Lopes E, Alpaugh M, Corben A, Riolo M, Beattie B, Pressl C, Peter RI, Xu C, Trondl R, Patel HJ, Shimizu F, Bolaender A, Yang C, Panchal P, Farooq MF, Kishinevsky S, Modi S, Lin O, Chu F, Patil S, Erdjument-Bromage H, Zanzonico P, Hudis C, Studer L, Roboz GJ, Cesarman E, Cerchietti L, Levine R, Melnick A, Larson SM, Lewis JS, Guzman ML, Chiosis G. Rodina A, et al. Among authors: studer l. Nature. 2016 Oct 20;538(7625):397-401. doi: 10.1038/nature19807. Epub 2016 Oct 5. Nature. 2016. PMID: 27706135 Free PMC article.
HSP90-incorporating chaperome networks as biosensor for disease-related pathways in patient-specific midbrain dopamine neurons.
Kishinevsky S, Wang T, Rodina A, Chung SY, Xu C, Philip J, Taldone T, Joshi S, Alpaugh ML, Bolaender A, Gutbier S, Sandhu D, Fattahi F, Zimmer B, Shah SK, Chang E, Inda C, Koren J 3rd, Saurat NG, Leist M, Gross SS, Seshan VE, Klein C, Tomishima MJ, Erdjument-Bromage H, Neubert TA, Henrickson RC, Chiosis G, Studer L. Kishinevsky S, et al. Among authors: studer l. Nat Commun. 2018 Oct 19;9(1):4345. doi: 10.1038/s41467-018-06486-6. Nat Commun. 2018. PMID: 30341316 Free PMC article.
A hPSC-based platform to discover gene-environment interactions that impact human β-cell and dopamine neuron survival.
Zhou T, Kim TW, Chong CN, Tan L, Amin S, Sadat Badieyan Z, Mukherjee S, Ghazizadeh Z, Zeng H, Guo M, Crespo M, Zhang T, Kenyon R, Robinson CL, Apostolou E, Wang H, Xiang JZ, Evans T, Studer L, Chen S. Zhou T, et al. Among authors: studer l. Nat Commun. 2018 Nov 16;9(1):4815. doi: 10.1038/s41467-018-07201-1. Nat Commun. 2018. PMID: 30446643 Free PMC article.
Lipid Deprivation Induces a Stable, Naive-to-Primed Intermediate State of Pluripotency in Human PSCs.
Cornacchia D, Zhang C, Zimmer B, Chung SY, Fan Y, Soliman MA, Tchieu J, Chambers SM, Shah H, Paull D, Konrad C, Vincendeau M, Noggle SA, Manfredi G, Finley LWS, Cross JR, Betel D, Studer L. Cornacchia D, et al. Among authors: studer l. Cell Stem Cell. 2019 Jul 3;25(1):120-136.e10. doi: 10.1016/j.stem.2019.05.001. Epub 2019 May 30. Cell Stem Cell. 2019. PMID: 31155483 Free PMC article.
251 results