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Circulating PCSK9 is associated with liver biomarkers and hepatic steatosis.
Paquette M, Gauthier D, Chamberland A, Prat A, De Lucia Rolfe E, Rasmussen JJ, Kaduka L, Seidah NG, Bernard S, Christensen DL, Baass A. Paquette M, et al. Among authors: chamberland a. Clin Biochem. 2020 Mar;77:20-25. doi: 10.1016/j.clinbiochem.2020.01.003. Epub 2020 Jan 20. Clin Biochem. 2020. PMID: 31972148 Free PMC article.
In vivo evidence that furin from hepatocytes inactivates PCSK9.
Essalmani R, Susan-Resiga D, Chamberland A, Abifadel M, Creemers JW, Boileau C, Seidah NG, Prat A. Essalmani R, et al. Among authors: chamberland a. J Biol Chem. 2011 Feb 11;286(6):4257-63. doi: 10.1074/jbc.M110.192104. Epub 2010 Dec 8. J Biol Chem. 2011. PMID: 21147780 Free PMC article.
Circulating proprotein convertase subtilisin/kexin 9 (PCSK9) regulates VLDLR protein and triglyceride accumulation in visceral adipose tissue.
Roubtsova A, Munkonda MN, Awan Z, Marcinkiewicz J, Chamberland A, Lazure C, Cianflone K, Seidah NG, Prat A. Roubtsova A, et al. Among authors: chamberland a. Arterioscler Thromb Vasc Biol. 2011 Apr;31(4):785-91. doi: 10.1161/ATVBAHA.110.220988. Epub 2011 Jan 27. Arterioscler Thromb Vasc Biol. 2011. PMID: 21273557
Amyloid Precursor-like Protein 2 and Sortilin Do Not Regulate the PCSK9 Convertase-mediated Low Density Lipoprotein Receptor Degradation but Interact with Each Other.
Butkinaree C, Canuel M, Essalmani R, Poirier S, Benjannet S, Asselin MC, Roubtsova A, Hamelin J, Marcinkiewicz J, Chamberland A, Guillemot J, Mayer G, Sisodia SS, Jacob Y, Prat A, Seidah NG. Butkinaree C, et al. Among authors: chamberland a. J Biol Chem. 2015 Jul 24;290(30):18609-20. doi: 10.1074/jbc.M115.647180. Epub 2015 Jun 17. J Biol Chem. 2015. PMID: 26085104 Free PMC article.
58 results