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Cigarette smoke exposure enhances transforming acidic coiled-coil-containing protein 2 turnover and thereby promotes emphysema.
Mallampalli RK, Li X, Jang JH, Kaminski T, Hoji A, Coon T, Chandra D, Welty S, Teng Y, Sembrat J, Rojas M, Zhao Y, Lafyatis R, Zou C, Sciurba F, Sundd P, Lan L, Nyunoya T. Mallampalli RK, et al. Among authors: lafyatis r. JCI Insight. 2020 Jan 30;5(2):e125895. doi: 10.1172/jci.insight.125895. JCI Insight. 2020. PMID: 31996486 Free PMC article.
Proliferating SPP1/MERTK-expressing macrophages in idiopathic pulmonary fibrosis.
Morse C, Tabib T, Sembrat J, Buschur KL, Bittar HT, Valenzi E, Jiang Y, Kass DJ, Gibson K, Chen W, Mora A, Benos PV, Rojas M, Lafyatis R. Morse C, et al. Among authors: lafyatis r. Eur Respir J. 2019 Aug 22;54(2):1802441. doi: 10.1183/13993003.02441-2018. Print 2019 Aug. Eur Respir J. 2019. PMID: 31221805 Free PMC article.
GDF15 is an epithelial-derived biomarker of idiopathic pulmonary fibrosis.
Zhang Y, Jiang M, Nouraie M, Roth MG, Tabib T, Winters S, Chen X, Sembrat J, Chu Y, Cardenes N, Tuder RM, Herzog EL, Ryu C, Rojas M, Lafyatis R, Gibson KF, McDyer JF, Kass DJ, Alder JK. Zhang Y, et al. Among authors: lafyatis r. Am J Physiol Lung Cell Mol Physiol. 2019 Oct 1;317(4):L510-L521. doi: 10.1152/ajplung.00062.2019. Epub 2019 Aug 21. Am J Physiol Lung Cell Mol Physiol. 2019. PMID: 31432710 Free PMC article.
KIAA0317 regulates pulmonary inflammation through SOCS2 degradation.
Lear TB, McKelvey AC, Evankovich JW, Rajbhandari S, Coon TA, Dunn SR, Londino JD, McVerry BJ, Zhang Y, Valenzi E, Burton CL, Gordon R, Gingras S, Lockwood KC, Jurczak MJ, Lafyatis R, Shlomchik MJ, Liu Y, Chen BB. Lear TB, et al. Among authors: lafyatis r. JCI Insight. 2019 Oct 3;4(19):e129110. doi: 10.1172/jci.insight.129110. JCI Insight. 2019. PMID: 31578312 Free PMC article.
Single cell RNA sequencing identifies IGFBP5 and QKI as ciliated epithelial cell genes associated with severe COPD.
Li X, Noell G, Tabib T, Gregory AD, Trejo Bittar HE, Vats R, Kaminski TW, Sembrat J, Snyder ME, Chandra D, Chen K, Zou C, Zhang Y, Sundd P, McDyer JF, Sciurba F, Rojas M, Lafyatis R, Shapiro SD, Faner R, Nyunoya T. Li X, et al. Among authors: lafyatis r. Respir Res. 2021 Apr 6;22(1):100. doi: 10.1186/s12931-021-01675-2. Respir Res. 2021. PMID: 33823868 Free PMC article.
Frataxin deficiency promotes endothelial senescence in pulmonary hypertension.
Culley MK, Zhao J, Tai YY, Tang Y, Perk D, Negi V, Yu Q, Woodcock CC, Handen A, Speyer G, Kim S, Lai YC, Satoh T, Watson AM, Aaraj YA, Sembrat J, Rojas M, Goncharov D, Goncharova EA, Khan OF, Anderson DG, Dahlman JE, Gurkar AU, Lafyatis R, Fayyaz AU, Redfield MM, Gladwin MT, Rabinovitch M, Gu M, Bertero T, Chan SY. Culley MK, et al. Among authors: lafyatis r. J Clin Invest. 2021 Jun 1;131(11):e136459. doi: 10.1172/JCI136459. J Clin Invest. 2021. PMID: 33905372 Free PMC article.
259 results