Engelman AN - Search Results

1

Structural basis of second-generation HIV integrase inhibitor action and viral resistance.

Cook NJ, Li W, Berta D, Badaoui M, Ballandras-Colas A, Nans A, Kotecha A, Rosta E, Engelman AN, Cherepanov P. Cook NJ, et al. Among authors: engelman an. Science. 2020 Feb 14;367(6479):806-810. doi: 10.1126/science.aay4919. Epub 2020 Jan 30. Science. 2020. PMID: 32001525 Free PMC article.

2

Identification and characterization of a functional nuclear localization signal in the HIV-1 integrase interactor LEDGF/p75.

Maertens G, Cherepanov P, Debyser Z, Engelborghs Y, Engelman A. Maertens G, et al. J Biol Chem. 2004 Aug 6;279(32):33421-9. doi: 10.1074/jbc.M404700200. Epub 2004 May 25. J Biol Chem. 2004. PMID: 15163664 Free article.

3

Identification of an evolutionarily conserved domain in human lens epithelium-derived growth factor/transcriptional co-activator p75 (LEDGF/p75) that binds HIV-1 integrase.

Cherepanov P, Devroe E, Silver PA, Engelman A. Cherepanov P, et al. J Biol Chem. 2004 Nov 19;279(47):48883-92. doi: 10.1074/jbc.M406307200. Epub 2004 Sep 14. J Biol Chem. 2004. PMID: 15371438 Free article.

4

Class II integrase mutants with changes in putative nuclear localization signals are primarily blocked at a postnuclear entry step of human immunodeficiency virus type 1 replication.

Lu R, Limón A, Devroe E, Silver PA, Cherepanov P, Engelman A. Lu R, et al. J Virol. 2004 Dec;78(23):12735-46. doi: 10.1128/JVI.78.23.12735-12746.2004. J Virol. 2004. PMID: 15542626 Free PMC article.

5

Solution structure of the HIV-1 integrase-binding domain in LEDGF/p75.

Cherepanov P, Sun ZY, Rahman S, Maertens G, Wagner G, Engelman A. Cherepanov P, et al. Nat Struct Mol Biol. 2005 Jun;12(6):526-32. doi: 10.1038/nsmb937. Epub 2005 May 15. Nat Struct Mol Biol. 2005. PMID: 15895093

6

Lys-34, dispensable for integrase catalysis, is required for preintegration complex function and human immunodeficiency virus type 1 replication.

Lu R, Vandegraaff N, Cherepanov P, Engelman A. Lu R, et al. J Virol. 2005 Oct;79(19):12584-91. doi: 10.1128/JVI.79.19.12584-12591.2005. J Virol. 2005. PMID: 16160186 Free PMC article.

7

Structural basis for the recognition between HIV-1 integrase and transcriptional coactivator p75.

Cherepanov P, Ambrosio AL, Rahman S, Ellenberger T, Engelman A. Cherepanov P, et al. Proc Natl Acad Sci U S A. 2005 Nov 29;102(48):17308-13. doi: 10.1073/pnas.0506924102. Epub 2005 Oct 31. Proc Natl Acad Sci U S A. 2005. PMID: 16260736 Free PMC article.

8

A tripartite DNA-binding element, comprised of the nuclear localization signal and two AT-hook motifs, mediates the association of LEDGF/p75 with chromatin in vivo.

Turlure F, Maertens G, Rahman S, Cherepanov P, Engelman A. Turlure F, et al. Nucleic Acids Res. 2006 Mar 20;34(5):1653-65. doi: 10.1093/nar/gkl052. Print 2006. Nucleic Acids Res. 2006. PMID: 16549878 Free PMC article.

9

Transcriptional co-activator p75 binds and tethers the Myc-interacting protein JPO2 to chromatin.

Maertens GN, Cherepanov P, Engelman A. Maertens GN, et al. J Cell Sci. 2006 Jun 15;119(Pt 12):2563-71. doi: 10.1242/jcs.02995. Epub 2006 May 30. J Cell Sci. 2006. PMID: 16735438

10

Structure-based mutagenesis of the integrase-LEDGF/p75 interface uncouples a strict correlation between in vitro protein binding and HIV-1 fitness.

Rahman S, Lu R, Vandegraaff N, Cherepanov P, Engelman A. Rahman S, et al. Virology. 2007 Jan 5;357(1):79-90. doi: 10.1016/j.virol.2006.08.011. Epub 2006 Sep 7. Virology. 2007. PMID: 16959283 Free article.

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