Garcia-Ocana A - Search Results

1

Synthesis and Biological Validation of a Harmine-Based, Central Nervous System (CNS)-Avoidant, Selective, Human β-Cell Regenerative Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase A (DYRK1A) Inhibitor.

Kumar K, Wang P, Wilson J, Zlatanic V, Berrouet C, Khamrui S, Secor C, Swartz EA, Lazarus M, Sanchez R, Stewart AF, Garcia-Ocana A, DeVita RJ. Kumar K, et al. J Med Chem. 2020 Mar 26;63(6):2986-3003. doi: 10.1021/acs.jmedchem.9b01379. Epub 2020 Feb 19. J Med Chem. 2020. PMID: 32003560 Free PMC article.

2

Adenovirus-mediated hepatocyte growth factor expression in mouse islets improves pancreatic islet transplant performance and reduces beta cell death.

Garcia-Ocana A, Takane KK, Reddy VT, Lopez-Talavera JC, Vasavada RC, Stewart AF. Garcia-Ocana A, et al. J Biol Chem. 2003 Jan 3;278(1):343-51. doi: 10.1074/jbc.M207848200. Epub 2002 Oct 25. J Biol Chem. 2003. PMID: 12403787 Free article.

3

Molecular control of cell cycle progression in the pancreatic beta-cell.

Cozar-Castellano I, Fiaschi-Taesch N, Bigatel TA, Takane KK, Garcia-Ocaña A, Vasavada R, Stewart AF. Cozar-Castellano I, et al. Endocr Rev. 2006 Jun;27(4):356-70. doi: 10.1210/er.2006-0004. Epub 2006 Apr 25. Endocr Rev. 2006. PMID: 16638909 Review.

4

Improving islet transplantation by gene delivery of hepatocyte growth factor (HGF) and its downstream target, protein kinase B (PKB)/Akt.

Fiaschi-Taesch N, Stewart AF, Garcia-Ocaña A. Fiaschi-Taesch N, et al. Cell Biochem Biophys. 2007;48(2-3):191-9. doi: 10.1007/s12013-007-0024-7. Cell Biochem Biophys. 2007. PMID: 17709889 Review.

5

Hepatocyte growth factor enhances engraftment and function of nonhuman primate islets.

Fiaschi-Taesch NM, Berman DM, Sicari BM, Takane KK, Garcia-Ocaña A, Ricordi C, Kenyon NS, Stewart AF. Fiaschi-Taesch NM, et al. Diabetes. 2008 Oct;57(10):2745-54. doi: 10.2337/db08-1085. Diabetes. 2008. PMID: 18820214 Free PMC article.

6

Parathyroid hormone-related protein enhances human ß-cell proliferation and function with associated induction of cyclin-dependent kinase 2 and cyclin E expression.

Guthalu Kondegowda N, Joshi-Gokhale S, Harb G, Williams K, Zhang XY, Takane KK, Zhang P, Scott DK, Stewart AF, Garcia-Ocaña A, Vasavada RC. Guthalu Kondegowda N, et al. Diabetes. 2010 Dec;59(12):3131-8. doi: 10.2337/db09-1796. Epub 2010 Sep 28. Diabetes. 2010. PMID: 20876711 Free PMC article.

7

Disruption of hepatocyte growth factor/c-Met signaling enhances pancreatic beta-cell death and accelerates the onset of diabetes.

Mellado-Gil J, Rosa TC, Demirci C, Gonzalez-Pertusa JA, Velazquez-Garcia S, Ernst S, Valle S, Vasavada RC, Stewart AF, Alonso LC, Garcia-Ocaña A. Mellado-Gil J, et al. Diabetes. 2011 Feb;60(2):525-36. doi: 10.2337/db09-1305. Epub 2010 Oct 27. Diabetes. 2011. PMID: 20980460 Free PMC article.

8

ChREBP mediates glucose-stimulated pancreatic β-cell proliferation.

Metukuri MR, Zhang P, Basantani MK, Chin C, Stamateris RE, Alonso LC, Takane KK, Gramignoli R, Strom SC, O'Doherty RM, Stewart AF, Vasavada RC, Garcia-Ocaña A, Scott DK. Metukuri MR, et al. Diabetes. 2012 Aug;61(8):2004-15. doi: 10.2337/db11-0802. Epub 2012 May 14. Diabetes. 2012. PMID: 22586588 Free PMC article.

9

Human β-cell proliferation and intracellular signaling part 2: still driving in the dark without a road map.

Bernal-Mizrachi E, Kulkarni RN, Scott DK, Mauvais-Jarvis F, Stewart AF, Garcia-Ocaña A. Bernal-Mizrachi E, et al. Diabetes. 2014 Mar;63(3):819-31. doi: 10.2337/db13-1146. Diabetes. 2014. PMID: 24556859 Free PMC article. Review.

10

"RAS"ling β cells to proliferate for diabetes: why do we need MEN?

García-Ocaña A, Stewart AF. García-Ocaña A, et al. J Clin Invest. 2014 Sep;124(9):3698-700. doi: 10.1172/JCI77764. Epub 2014 Aug 18. J Clin Invest. 2014. PMID: 25133422 Free PMC article.

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