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Comparative studies on the effects of sodium phenobarbital and two other constitutive androstane receptor (CAR) activators on induction of cytochrome P450 enzymes and replicative DNA synthesis in cultured hepatocytes from wild type and CAR knockout rats.
Goettel M, Fegert I, Honarvar N, Vardy A, Haines C, Chatham LR, Lake BG. Goettel M, et al. Among authors: lake bg. Toxicology. 2020 Mar 30;433-434:152394. doi: 10.1016/j.tox.2020.152394. Epub 2020 Feb 3. Toxicology. 2020. PMID: 32027962
Comparison of the hepatic and thyroid gland effects of sodium phenobarbital in wild type and constitutive androstane receptor (CAR) knockout rats and pregnenolone-16α-carbonitrile in wild type and pregnane X receptor (PXR) knockout rats.
Haines C, Chatham LR, Vardy A, Elcombe CR, Foster JR, Lake BG. Haines C, et al. Among authors: lake bg. Toxicology. 2018 May 1;400-401:20-27. doi: 10.1016/j.tox.2018.03.002. Epub 2018 Mar 13. Toxicology. 2018. PMID: 29548889
Mode of action and human relevance analysis for nuclear receptor-mediated liver toxicity: A case study with phenobarbital as a model constitutive androstane receptor (CAR) activator.
Elcombe CR, Peffer RC, Wolf DC, Bailey J, Bars R, Bell D, Cattley RC, Ferguson SS, Geter D, Goetz A, Goodman JI, Hester S, Jacobs A, Omiecinski CJ, Schoeny R, Xie W, Lake BG. Elcombe CR, et al. Among authors: lake bg. Crit Rev Toxicol. 2014 Jan;44(1):64-82. doi: 10.3109/10408444.2013.835786. Epub 2013 Nov 4. Crit Rev Toxicol. 2014. PMID: 24180433 Free PMC article. Review.
285 results