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Page 1
Dynamic Imaging of LDH Inhibition in Tumors Reveals Rapid In Vivo Metabolic Rewiring and Vulnerability to Combination Therapy.
Oshima N, Ishida R, Kishimoto S, Beebe K, Brender JR, Yamamoto K, Urban D, Rai G, Johnson MS, Benavides G, Squadrito GL, Crooks D, Jackson J, Joshi A, Mott BT, Shrimp JH, Moses MA, Lee MJ, Yuno A, Lee TD, Hu X, Anderson T, Kusewitt D, Hathaway HH, Jadhav A, Picard D, Trepel JB, Mitchell JB, Stott GM, Moore W, Simeonov A, Sklar LA, Norenberg JP, Linehan WM, Maloney DJ, Dang CV, Waterson AG, Hall M, Darley-Usmar VM, Krishna MC, Neckers LM. Oshima N, et al. Among authors: dang cv. Cell Rep. 2020 Feb 11;30(6):1798-1810.e4. doi: 10.1016/j.celrep.2020.01.039. Cell Rep. 2020. PMID: 32049011 Free PMC article.
Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH).
Rai G, Brimacombe KR, Mott BT, Urban DJ, Hu X, Yang SM, Lee TD, Cheff DM, Kouznetsova J, Benavides GA, Pohida K, Kuenstner EJ, Luci DK, Lukacs CM, Davies DR, Dranow DM, Zhu H, Sulikowski G, Moore WJ, Stott GM, Flint AJ, Hall MD, Darley-Usmar VM, Neckers LM, Dang CV, Waterson AG, Simeonov A, Jadhav A, Maloney DJ. Rai G, et al. Among authors: dang cv. J Med Chem. 2017 Nov 22;60(22):9184-9204. doi: 10.1021/acs.jmedchem.7b00941. Epub 2017 Nov 9. J Med Chem. 2017. PMID: 29120638 Free PMC article.
Pyrazole-Based Lactate Dehydrogenase Inhibitors with Optimized Cell Activity and Pharmacokinetic Properties.
Rai G, Urban DJ, Mott BT, Hu X, Yang SM, Benavides GA, Johnson MS, Squadrito GL, Brimacombe KR, Lee TD, Cheff DM, Zhu H, Henderson MJ, Pohida K, Sulikowski GA, Dranow DM, Kabir M, Shah P, Padilha E, Tao D, Fang Y, Christov PP, Kim K, Jana S, Muttil P, Anderson T, Kunda NK, Hathaway HJ, Kusewitt DF, Oshima N, Cherukuri M, Davies DR, Norenberg JP, Sklar LA, Moore WJ, Dang CV, Stott GM, Neckers L, Flint AJ, Darley-Usmar VM, Simeonov A, Waterson AG, Jadhav A, Hall MD, Maloney DJ. Rai G, et al. Among authors: dang cv. J Med Chem. 2020 Oct 8;63(19):10984-11011. doi: 10.1021/acs.jmedchem.0c00916. Epub 2020 Sep 27. J Med Chem. 2020. PMID: 32902275 Free PMC article.
Androgen receptor drives polyamine synthesis creating a vulnerability for prostate cancer.
Kumar R, Jonnatan S, Sanin DE, Vakkala V, Kadam A, Kumar S, Dalrymple SL, Zhao L, Foley J, Holbert CE, Nwafor A, Kittane S, Penner E, Apostolova P, Warner S, Dang CV, Toska E, Thompson EA, Isaacs JT, De Marzo AM, Pearce EL, Stewart TM, Casero RA, Denmeade SR, Sena LA. Kumar R, et al. Among authors: dang cv. medRxiv [Preprint]. 2024 Dec 13:2024.12.12.24318845. doi: 10.1101/2024.12.12.24318845. medRxiv. 2024. PMID: 39711733 Free PMC article. Preprint.
Hypermetabolic state is associated with circadian rhythm disruption in mouse and human cancer cells.
Iascone DM, Zhang X, Brafford P, Mesaros C, Sela Y, Hofbauer S, Zhang SL, Madhwal S, Cook K, Pivarshev P, Stanger BZ, Anderson S, Dang CV, Sehgal A. Iascone DM, et al. Among authors: dang cv. Proc Natl Acad Sci U S A. 2024 Jul 23;121(30):e2319782121. doi: 10.1073/pnas.2319782121. Epub 2024 Jul 15. Proc Natl Acad Sci U S A. 2024. PMID: 39008664 Free PMC article.
Lineage-dependence of the neuroblastoma surfaceome defines tumor cell state-dependent and independent immunotherapeutic targets.
Kendsersky NM, Odrobina M, Mabe NW, Farrel A, Grossmann L, Tsang M, Groff D, Wolpaw AJ, Zammarchi F, van Berkel PH, Dang CV, Mossé YP, Stegmaier K, Maris JM. Kendsersky NM, et al. Among authors: dang cv. bioRxiv [Preprint]. 2024 Jul 2:2024.06.27.600865. doi: 10.1101/2024.06.27.600865. bioRxiv. 2024. PMID: 39005383 Free PMC article. Preprint.
Clocking Cancer Immunotherapy Responses.
Wang CL, Zhang X, Dang CV. Wang CL, et al. Among authors: dang cv. Cancer Res. 2024 Sep 4;84(17):2756-2758. doi: 10.1158/0008-5472.CAN-24-2083. Cancer Res. 2024. PMID: 38924465
ACLY alternative splicing correlates with cancer phenotypes.
Supplee JG, Affronti HC, Duan R, Brooks RC, Stine ZE, Nguyen PTT, Pinheiro LV, Noji MC, Drummond JM, Huang K, Schultz K, Dang CV, Marmorstein R, Wellen KE. Supplee JG, et al. Among authors: dang cv. J Biol Chem. 2024 Jul;300(7):107418. doi: 10.1016/j.jbc.2024.107418. Epub 2024 May 28. J Biol Chem. 2024. PMID: 38815867 Free PMC article.
333 results