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Dynamic Imaging of LDH Inhibition in Tumors Reveals Rapid In Vivo Metabolic Rewiring and Vulnerability to Combination Therapy.
Oshima N, Ishida R, Kishimoto S, Beebe K, Brender JR, Yamamoto K, Urban D, Rai G, Johnson MS, Benavides G, Squadrito GL, Crooks D, Jackson J, Joshi A, Mott BT, Shrimp JH, Moses MA, Lee MJ, Yuno A, Lee TD, Hu X, Anderson T, Kusewitt D, Hathaway HH, Jadhav A, Picard D, Trepel JB, Mitchell JB, Stott GM, Moore W, Simeonov A, Sklar LA, Norenberg JP, Linehan WM, Maloney DJ, Dang CV, Waterson AG, Hall M, Darley-Usmar VM, Krishna MC, Neckers LM. Oshima N, et al. Among authors: kishimoto s. Cell Rep. 2020 Feb 11;30(6):1798-1810.e4. doi: 10.1016/j.celrep.2020.01.039. Cell Rep. 2020. PMID: 32049011 Free PMC article.
Pyruvate induces transient tumor hypoxia by enhancing mitochondrial oxygen consumption and potentiates the anti-tumor effect of a hypoxia-activated prodrug TH-302.
Takakusagi Y, Matsumoto S, Saito K, Matsuo M, Kishimoto S, Wojtkowiak JW, DeGraff W, Kesarwala AH, Choudhuri R, Devasahayam N, Subramanian S, Munasinghe JP, Gillies RJ, Mitchell JB, Hart CP, Krishna MC. Takakusagi Y, et al. Among authors: kishimoto s. PLoS One. 2014 Sep 25;9(9):e107995. doi: 10.1371/journal.pone.0107995. eCollection 2014. PLoS One. 2014. PMID: 25254649 Free PMC article.
Multimodality Imaging Identifies Distinct Metabolic Profiles In Vitro and In Vivo.
Neveu MA, De Preter G, Marchand V, Bol A, Brender JR, Saito K, Kishimoto S, Porporato PE, Sonveaux P, Grégoire V, Feron O, Jordan BF, Krishna MC, Gallez B. Neveu MA, et al. Among authors: kishimoto s. Neoplasia. 2016 Dec;18(12):742-752. doi: 10.1016/j.neo.2016.10.010. Epub 2016 Nov 24. Neoplasia. 2016. PMID: 27889643 Free PMC article.
In Vivo Application of Proton-Electron Double-Resonance Imaging.
Kishimoto S, Krishna MC, Khramtsov VV, Utsumi H, Lurie DJ. Kishimoto S, et al. Antioxid Redox Signal. 2018 May 20;28(15):1345-1364. doi: 10.1089/ars.2017.7341. Epub 2017 Nov 13. Antioxid Redox Signal. 2018. PMID: 28990406 Free PMC article. Review.
1,184 results