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Page 1
Dynamic Imaging of LDH Inhibition in Tumors Reveals Rapid In Vivo Metabolic Rewiring and Vulnerability to Combination Therapy.
Oshima N, Ishida R, Kishimoto S, Beebe K, Brender JR, Yamamoto K, Urban D, Rai G, Johnson MS, Benavides G, Squadrito GL, Crooks D, Jackson J, Joshi A, Mott BT, Shrimp JH, Moses MA, Lee MJ, Yuno A, Lee TD, Hu X, Anderson T, Kusewitt D, Hathaway HH, Jadhav A, Picard D, Trepel JB, Mitchell JB, Stott GM, Moore W, Simeonov A, Sklar LA, Norenberg JP, Linehan WM, Maloney DJ, Dang CV, Waterson AG, Hall M, Darley-Usmar VM, Krishna MC, Neckers LM. Oshima N, et al. Among authors: linehan wm. Cell Rep. 2020 Feb 11;30(6):1798-1810.e4. doi: 10.1016/j.celrep.2020.01.039. Cell Rep. 2020. PMID: 32049011 Free PMC article.
HIF and fumarate hydratase in renal cancer.
Sudarshan S, Linehan WM, Neckers L. Sudarshan S, et al. Among authors: linehan wm. Br J Cancer. 2007 Feb 12;96(3):403-7. doi: 10.1038/sj.bjc.6603547. Epub 2007 Jan 9. Br J Cancer. 2007. PMID: 17211469 Free PMC article. Review.
Inhibition of tumor cell motility by the interferon-inducible GTPase MxA.
Mushinski JF, Nguyen P, Stevens LM, Khanna C, Lee S, Chung EJ, Lee MJ, Kim YS, Linehan WM, Horisberger MA, Trepel JB. Mushinski JF, et al. Among authors: linehan wm. J Biol Chem. 2009 May 29;284(22):15206-14. doi: 10.1074/jbc.M806324200. Epub 2009 Mar 18. J Biol Chem. 2009. PMID: 19297326 Free PMC article.
Fumarate hydratase deficiency in renal cancer induces glycolytic addiction and hypoxia-inducible transcription factor 1alpha stabilization by glucose-dependent generation of reactive oxygen species.
Sudarshan S, Sourbier C, Kong HS, Block K, Valera Romero VA, Yang Y, Galindo C, Mollapour M, Scroggins B, Goode N, Lee MJ, Gourlay CW, Trepel J, Linehan WM, Neckers L. Sudarshan S, et al. Among authors: linehan wm. Mol Cell Biol. 2009 Aug;29(15):4080-90. doi: 10.1128/MCB.00483-09. Epub 2009 May 26. Mol Cell Biol. 2009. PMID: 19470762 Free PMC article.
Targeting ABL1-mediated oxidative stress adaptation in fumarate hydratase-deficient cancer.
Sourbier C, Ricketts CJ, Matsumoto S, Crooks DR, Liao PJ, Mannes PZ, Yang Y, Wei MH, Srivastava G, Ghosh S, Chen V, Vocke CD, Merino M, Srinivasan R, Krishna MC, Mitchell JB, Pendergast AM, Rouault TA, Neckers L, Linehan WM. Sourbier C, et al. Among authors: linehan wm. Cancer Cell. 2014 Dec 8;26(6):840-850. doi: 10.1016/j.ccell.2014.10.005. Cancer Cell. 2014. PMID: 25490448 Free PMC article.
Alternative splicing of the cell fate determinant Numb in hepatocellular carcinoma.
Lu Y, Xu W, Ji J, Feng D, Sourbier C, Yang Y, Qu J, Zeng Z, Wang C, Chang X, Chen Y, Mishra A, Xu M, Lee MJ, Lee S, Trepel J, Linehan WM, Wang X, Yang Y, Neckers L. Lu Y, et al. Among authors: linehan wm. Hepatology. 2015 Oct;62(4):1122-31. doi: 10.1002/hep.27923. Epub 2015 Jul 3. Hepatology. 2015. PMID: 26058814 Free PMC article.
816 results