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Persistent Polyfunctional Chimeric Antigen Receptor T Cells That Target Glypican 3 Eliminate Orthotopic Hepatocellular Carcinomas in Mice.
Li D, Li N, Zhang YF, Fu H, Feng M, Schneider D, Su L, Wu X, Zhou J, Mackay S, Kramer J, Duan Z, Yang H, Kolluri A, Hummer AM, Torres MB, Zhu H, Hall MD, Luo X, Chen J, Wang Q, Abate-Daga D, Dropulic B, Hewitt SM, Orentas RJ, Greten TF, Ho M. Li D, et al. Among authors: hewitt sm. Gastroenterology. 2020 Jun;158(8):2250-2265.e20. doi: 10.1053/j.gastro.2020.02.011. Epub 2020 Feb 12. Gastroenterology. 2020. PMID: 32060001 Free PMC article.
Human CCR4+ CCR6+ Th17 cells suppress autologous CD8+ T cell responses.
Zhao F, Hoechst B, Gamrekelashvili J, Ormandy LA, Voigtländer T, Wedemeyer H, Ylaya K, Wang XW, Hewitt SM, Manns MP, Korangy F, Greten TF. Zhao F, et al. Among authors: hewitt sm. J Immunol. 2012 Jun 15;188(12):6055-62. doi: 10.4049/jimmunol.1102918. Epub 2012 May 21. J Immunol. 2012. PMID: 22615204 Free PMC article.
Multiple chimeric antigen receptors successfully target chondroitin sulfate proteoglycan 4 in several different cancer histologies and cancer stem cells.
Beard RE, Zheng Z, Lagisetty KH, Burns WR, Tran E, Hewitt SM, Abate-Daga D, Rosati SF, Fine HA, Ferrone S, Rosenberg SA, Morgan RA. Beard RE, et al. Among authors: hewitt sm. J Immunother Cancer. 2014 Aug 19;2:25. doi: 10.1186/2051-1426-2-25. eCollection 2014. J Immunother Cancer. 2014. PMID: 25197555 Free PMC article.
Tumor Cell Biodiversity Drives Microenvironmental Reprogramming in Liver Cancer.
Ma L, Hernandez MO, Zhao Y, Mehta M, Tran B, Kelly M, Rae Z, Hernandez JM, Davis JL, Martin SP, Kleiner DE, Hewitt SM, Ylaya K, Wood BJ, Greten TF, Wang XW. Ma L, et al. Among authors: hewitt sm. Cancer Cell. 2019 Oct 14;36(4):418-430.e6. doi: 10.1016/j.ccell.2019.08.007. Epub 2019 Oct 3. Cancer Cell. 2019. PMID: 31588021 Free PMC article.
CAR T cells targeting tumor-associated exons of glypican 2 regress neuroblastoma in mice.
Li N, Torres MB, Spetz MR, Wang R, Peng L, Tian M, Dower CM, Nguyen R, Sun M, Tai CH, de Val N, Cachau R, Wu X, Hewitt SM, Kaplan RN, Khan J, St Croix B, Thiele CJ, Ho M. Li N, et al. Among authors: hewitt sm. Cell Rep Med. 2021 Jun 1;2(6):100297. doi: 10.1016/j.xcrm.2021.100297. eCollection 2021 Jun 15. Cell Rep Med. 2021. PMID: 34195677 Free PMC article.
Multiregional single-cell dissection of tumor and immune cells reveals stable lock-and-key features in liver cancer.
Ma L, Heinrich S, Wang L, Keggenhoff FL, Khatib S, Forgues M, Kelly M, Hewitt SM, Saif A, Hernandez JM, Mabry D, Kloeckner R, Greten TF, Chaisaingmongkol J, Ruchirawat M, Marquardt JU, Wang XW. Ma L, et al. Among authors: hewitt sm. Nat Commun. 2022 Dec 7;13(1):7533. doi: 10.1038/s41467-022-35291-5. Nat Commun. 2022. PMID: 36476645 Free PMC article.
485 results