Kearse MG - Search Results

1

A native function for RAN translation and CGG repeats in regulating fragile X protein synthesis.

Rodriguez CM, Wright SE, Kearse MG, Haenfler JM, Flores BN, Liu Y, Ifrim MF, Glineburg MR, Krans A, Jafar-Nejad P, Sutton MA, Bassell GJ, Parent JM, Rigo F, Barmada SJ, Todd PK. Rodriguez CM, et al. Among authors: kearse mg. Nat Neurosci. 2020 Mar;23(3):386-397. doi: 10.1038/s41593-020-0590-1. Epub 2020 Feb 17. Nat Neurosci. 2020. PMID: 32066985 Free PMC article.

2

Repeat-associated non-AUG translation and its impact in neurodegenerative disease.

Kearse MG, Todd PK. Kearse MG, et al. Neurotherapeutics. 2014 Oct;11(4):721-31. doi: 10.1007/s13311-014-0292-z. Neurotherapeutics. 2014. PMID: 25005000 Free PMC article. Review.

3

CGG Repeat-Associated Non-AUG Translation Utilizes a Cap-Dependent Scanning Mechanism of Initiation to Produce Toxic Proteins.

Kearse MG, Green KM, Krans A, Rodriguez CM, Linsalata AE, Goldstrohm AC, Todd PK. Kearse MG, et al. Mol Cell. 2016 Apr 21;62(2):314-322. doi: 10.1016/j.molcel.2016.02.034. Epub 2016 Mar 31. Mol Cell. 2016. PMID: 27041225 Free PMC article.

4

Repeat-associated non-AUG translation from antisense CCG repeats in fragile X tremor/ataxia syndrome.

Krans A, Kearse MG, Todd PK. Krans A, et al. Among authors: kearse mg. Ann Neurol. 2016 Dec;80(6):871-881. doi: 10.1002/ana.24800. Epub 2016 Nov 26. Ann Neurol. 2016. PMID: 27761921 Free PMC article.

5

RAN translation at C9orf72-associated repeat expansions is selectively enhanced by the integrated stress response.

Green KM, Glineburg MR, Kearse MG, Flores BN, Linsalata AE, Fedak SJ, Goldstrohm AC, Barmada SJ, Todd PK. Green KM, et al. Among authors: kearse mg. Nat Commun. 2017 Dec 8;8(1):2005. doi: 10.1038/s41467-017-02200-0. Nat Commun. 2017. PMID: 29222490 Free PMC article.

6

Ribosome queuing enables non-AUG translation to be resistant to multiple protein synthesis inhibitors.

Kearse MG, Goldman DH, Choi J, Nwaezeapu C, Liang D, Green KM, Goldstrohm AC, Todd PK, Green R, Wilusz JE. Kearse MG, et al. Genes Dev. 2019 Jul 1;33(13-14):871-885. doi: 10.1101/gad.324715.119. Epub 2019 Jun 6. Genes Dev. 2019. PMID: 31171704 Free PMC article.

7

High-throughput screening yields several small-molecule inhibitors of repeat-associated non-AUG translation.

Green KM, Sheth UJ, Flores BN, Wright SE, Sutter AB, Kearse MG, Barmada SJ, Ivanova MI, Todd PK. Green KM, et al. Among authors: kearse mg. J Biol Chem. 2019 Dec 6;294(49):18624-18638. doi: 10.1074/jbc.RA119.009951. Epub 2019 Oct 23. J Biol Chem. 2019. PMID: 31649034 Free PMC article.

8

A noncanonical RNA-binding domain of the fragile X protein, FMRP, elicits translational repression independent of mRNA G-quadruplexes.

Scarpitti MR, Warrick JE, Yoder EL, Kearse MG. Scarpitti MR, et al. Among authors: kearse mg. J Biol Chem. 2022 Dec;298(12):102660. doi: 10.1016/j.jbc.2022.102660. Epub 2022 Oct 31. J Biol Chem. 2022. PMID: 36328245 Free PMC article.

9

Increased levels of eIF2A inhibit translation by sequestering 40S ribosomal subunits.

Grove DJ, Levine DJ, Kearse MG. Grove DJ, et al. Among authors: kearse mg. Nucleic Acids Res. 2023 Oct 13;51(18):9983-10000. doi: 10.1093/nar/gkad683. Nucleic Acids Res. 2023. PMID: 37602404 Free PMC article.

10

Non-AUG translation: a new start for protein synthesis in eukaryotes.

Kearse MG, Wilusz JE. Kearse MG, et al. Genes Dev. 2017 Sep 1;31(17):1717-1731. doi: 10.1101/gad.305250.117. Genes Dev. 2017. PMID: 28982758 Free PMC article. Review.

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