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OTULIN Prevents Liver Inflammation and Hepatocellular Carcinoma by Inhibiting FADD- and RIPK1 Kinase-Mediated Hepatocyte Apoptosis.
Verboom L, Martens A, Priem D, Hoste E, Sze M, Vikkula H, Van Hove L, Voet S, Roels J, Maelfait J, Bongiovanni L, de Bruin A, Scott CL, Saeys Y, Pasparakis M, Bertrand MJM, van Loo G. Verboom L, et al. Among authors: priem d. Cell Rep. 2020 Feb 18;30(7):2237-2247.e6. doi: 10.1016/j.celrep.2020.01.028. Cell Rep. 2020. PMID: 32075762 Free article.
MK2 phosphorylation of RIPK1 regulates TNF-mediated cell death.
Dondelinger Y, Delanghe T, Rojas-Rivera D, Priem D, Delvaeye T, Bruggeman I, Van Herreweghe F, Vandenabeele P, Bertrand MJM. Dondelinger Y, et al. Among authors: priem d. Nat Cell Biol. 2017 Oct;19(10):1237-1247. doi: 10.1038/ncb3608. Epub 2017 Sep 18. Nat Cell Biol. 2017. PMID: 28920952
Serine 25 phosphorylation inhibits RIPK1 kinase-dependent cell death in models of infection and inflammation.
Dondelinger Y, Delanghe T, Priem D, Wynosky-Dolfi MA, Sorobetea D, Rojas-Rivera D, Giansanti P, Roelandt R, Gropengiesser J, Ruckdeschel K, Savvides SN, Heck AJR, Vandenabeele P, Brodsky IE, Bertrand MJM. Dondelinger Y, et al. Among authors: priem d. Nat Commun. 2019 Apr 15;10(1):1729. doi: 10.1038/s41467-019-09690-0. Nat Commun. 2019. PMID: 30988283 Free PMC article.
Two distinct ubiquitin-binding motifs in A20 mediate its anti-inflammatory and cell-protective activities.
Martens A, Priem D, Hoste E, Vetters J, Rennen S, Catrysse L, Voet S, Deelen L, Sze M, Vikkula H, Slowicka K, Hochepied T, Iliaki K, Wullaert A, Janssens S, Lamkanfi M, Beyaert R, Armaka M, Bertrand MJM, van Loo G. Martens A, et al. Among authors: priem d. Nat Immunol. 2020 Apr;21(4):381-387. doi: 10.1038/s41590-020-0621-9. Epub 2020 Mar 16. Nat Immunol. 2020. PMID: 32205881
A20 and Cell Death-driven Inflammation.
Priem D, van Loo G, Bertrand MJM. Priem D, et al. Trends Immunol. 2020 May;41(5):421-435. doi: 10.1016/j.it.2020.03.001. Epub 2020 Mar 30. Trends Immunol. 2020. PMID: 32241683 Review.
A20 controls RANK-dependent osteoclast formation and bone physiology.
Martens A, Hertens P, Priem D, Rinotas V, Meletakos T, Gennadi M, Van Hove L, Louagie E, Coudenys J, De Muynck A, Gaublomme D, Sze M, van Hengel J, Catrysse L, Hoste E, Zajac JD, Davey RA, Van Hoorebeke L, Hochepied T, Bertrand MJM, Armaka M, Elewaut D, van Loo G. Martens A, et al. Among authors: priem d. EMBO Rep. 2022 Dec 6;23(12):e55233. doi: 10.15252/embr.202255233. Epub 2022 Oct 4. EMBO Rep. 2022. PMID: 36194667 Free PMC article.
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