Meanwell NA - Search Results

1

Discovery and Optimization of Novel Pyrazolopyrimidines as Potent and Orally Bioavailable Allosteric HIV-1 Integrase Inhibitors.

Li G, Meanwell NA, Krystal MR, Langley DR, Naidu BN, Sivaprakasam P, Lewis H, Kish K, Khan JA, Ng A, Trainor GL, Cianci C, Dicker IB, Walker MA, Lin Z, Protack T, Discotto L, Jenkins S, Gerritz SW, Pendri A. Li G, et al. Among authors: meanwell na. J Med Chem. 2020 Mar 12;63(5):2620-2637. doi: 10.1021/acs.jmedchem.9b01681. Epub 2020 Feb 21. J Med Chem. 2020. PMID: 32081010

2

Inhibitors of blood platelet cAMP phosphodiesterase. 2. Structure-activity relationships associated with 1,3-dihydro-2H-imidazo[4,5-b]quinolin-2-ones substituted with functionalized side chains.

Meanwell NA, Pearce BC, Roth HR, Smith EC, Wedding DL, Wright JJ, Buchanan JO, Baryla UM, Gamberdella M, Gillespie E, et al. Meanwell NA, et al. J Med Chem. 1992 Jul 10;35(14):2672-87. doi: 10.1021/jm00092a019. J Med Chem. 1992. PMID: 1321910

3

Inhibitors of blood platelet cAMP phosphodiesterase. 3. 1,3-Dihydro-2H-imidazo[4,5-b]quinolin-2-one derivatives with enhanced aqueous solubility.

Meanwell NA, Dennis RD, Roth HR, Rosenfeld MJ, Smith EC, Wright JJ, Buchanan JO, Brassard CL, Gamberdella M, Gillespie E, et al. Meanwell NA, et al. J Med Chem. 1992 Jul 10;35(14):2688-96. doi: 10.1021/jm00092a020. J Med Chem. 1992. PMID: 1321911

4

Structure-activity relationships associated with 3,4,5-triphenyl-1H-pyrazole-1-nonanoic acid, a nonprostanoid prostacyclin mimetic.

Meanwell NA, Rosenfeld MJ, Wright JJ, Brassard CL, Buchanan JO, Federici ME, Fleming JS, Seiler SM. Meanwell NA, et al. J Med Chem. 1992 Jan 24;35(2):389-97. doi: 10.1021/jm00080a028. J Med Chem. 1992. PMID: 1370696

5

Nonprostanoid prostacyclin mimetics. 2. 4,5-Diphenyloxazole derivatives.

Meanwell NA, Rosenfeld MJ, Trehan AK, Wright JJ, Brassard CL, Buchanan JO, Federici ME, Fleming JS, Gamberdella M, Zavoico GB, et al. Meanwell NA, et al. J Med Chem. 1992 Sep 18;35(19):3483-97. doi: 10.1021/jm00097a006. J Med Chem. 1992. PMID: 1404230

6

Nonprostanoid prostacyclin mimetics. 3. Structural variations of the diphenyl heterocycle moiety.

Meanwell NA, Rosenfeld MJ, Trehan AK, Romine JL, Wright JJ, Brassard CL, Buchanan JO, Federici ME, Fleming JS, Gamberdella M, et al. Meanwell NA, et al. J Med Chem. 1992 Sep 18;35(19):3498-512. doi: 10.1021/jm00097a007. J Med Chem. 1992. PMID: 1404231

7

1,3-Dihydro-2H-imidazo[4,5-b]quinolin-2-ones--inhibitors of blood platelet cAMP phosphodiesterase and induced aggregation.

Meanwell NA, Roth HR, Smith EC, Wedding DL, Wright JJ, Fleming JS, Gillespie E. Meanwell NA, et al. J Med Chem. 1991 Sep;34(9):2906-16. doi: 10.1021/jm00113a033. J Med Chem. 1991. PMID: 1654430

8

Active site-directed thrombin inhibitors--II. Studies related to arginine/guanidine bioisosteres.

St Laurent DR, Balasubramanian N, Han WT, Trehan A, Federici ME, Meanwell NA, Wright JJ, Seiler SM. St Laurent DR, et al. Among authors: meanwell na. Bioorg Med Chem. 1995 Aug;3(8):1145-56. doi: 10.1016/0968-0896(95)00103-n. Bioorg Med Chem. 1995. PMID: 7582986

9

Nonprostanoid prostacyclin mimetics. 4. Derivatives of 2-[3-[2-(4,5-diphenyl-2-oxazolyl)ethyl]phenoxy]acetic acid substituted alpha to the oxazole ring.

Meanwell NA, Rosenfeld MJ, Wright JJ, Brassard CL, Buchanan JO, Federici ME, Fleming JS, Gamberdella M, Hartl KS, Zavoico GB, et al. Meanwell NA, et al. J Med Chem. 1993 Nov 26;36(24):3871-83. doi: 10.1021/jm00076a017. J Med Chem. 1993. PMID: 8254619

10

Active site-directed synthetic thrombin inhibitors: synthesis, in vitro and in vivo activity profile of BMY 44621 and analogs. An examination of the role of the amino group in the D-Phe-Pro-Arg-H series.

Balasubramanian N, St Laurent DR, Federici ME, Meanwell NA, Wright JJ, Schumacher WA, Seiler SM. Balasubramanian N, et al. Among authors: meanwell na. J Med Chem. 1993 Jan 22;36(2):300-3. doi: 10.1021/jm00054a018. J Med Chem. 1993. PMID: 8423602 No abstract available.

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