Darpo B - Search Results

1

No QTc Prolongation With Zanubrutinib: Results of Concentration-QTc Analysis From a Thorough QT Study in Healthy Subjects.

Mu S, Darpo B, Tang Z, Novotny W, Tawashi M, Xue H, Willett M, Lin L, Sahasranaman S, Ou YC. Mu S, et al. Among authors: darpo b. Clin Transl Sci. 2020 Sep;13(5):923-931. doi: 10.1111/cts.12779. Epub 2020 Apr 8. Clin Transl Sci. 2020. PMID: 32144955 Free PMC article. Clinical Trial.

2

A thorough QTc study to evaluate the effects of oral rilzabrutinib administered alone and with ritonavir in healthy subjects.

Ucpinar S, Darpo B, Neale A, Nunn P, Shu J, Chu KA, Kavanagh M, Xue H, Phiasivongsa P, Thomas D, Smith PF. Ucpinar S, et al. Among authors: darpo b. Clin Transl Sci. 2022 Jun;15(6):1507-1518. doi: 10.1111/cts.13271. Epub 2022 Apr 3. Clin Transl Sci. 2022. PMID: 35301810 Free PMC article. Clinical Trial.

3

Thorough QT/QTc Evaluation of the Cardiac Safety of Secnidazole at Therapeutic and Supratherapeutic Doses in Healthy Individuals.

Darpo B, Xue H, Adetoro N, Matthews BG, Pentikis HS. Darpo B, et al. J Clin Pharmacol. 2018 Mar;58(3):286-293. doi: 10.1002/jcph.1014. Epub 2017 Oct 2. J Clin Pharmacol. 2018. PMID: 28967984 Free PMC article. Clinical Trial.

4

Randomized, Double-Blind, Placebo- and Positive-Controlled Crossover Study of the Effects of Omadacycline on QT/QTc Intervals in Healthy Subjects.

Darpo B, Xue H, Tanaka SK, Tzanis E. Darpo B, et al. Antimicrob Agents Chemother. 2019 Sep 23;63(10):e00922-19. doi: 10.1128/AAC.00922-19. Print 2019 Oct. Antimicrob Agents Chemother. 2019. PMID: 31405867 Free PMC article. Clinical Trial.

5

Revefenacin, a Long-Acting Muscarinic Antagonist, Does Not Prolong QT Interval in Healthy Subjects: Results of a Placebo- and Positive-Controlled Thorough QT Study.

Borin MT, Barnes CN, Darpo B, Pendyala S, Xue H, Bourdet DL. Borin MT, et al. Among authors: darpo b. Clin Pharmacol Drug Dev. 2020 Jan;9(1):130-139. doi: 10.1002/cpdd.732. Epub 2019 Aug 29. Clin Pharmacol Drug Dev. 2020. PMID: 31468714 Free PMC article. Clinical Trial.

6

Evaluation of the Potential for QTc Prolongation With Repeated Oral Doses of Fedratinib in Patients With Advanced Solid Tumors.

Ogasawara K, Xu C, Yin J, Darpo B, Carayannopoulos L, Xue H, Palmisano M, Krishna G. Ogasawara K, et al. Among authors: darpo b. Clin Pharmacol Drug Dev. 2021 Apr;10(4):366-375. doi: 10.1002/cpdd.850. Epub 2020 Jul 16. Clin Pharmacol Drug Dev. 2021. PMID: 32673446 Clinical Trial.

7

The effect of the glucosylceramide synthase inhibitor lucerastat on cardiac repolarization: results from a thorough QT study in healthy subjects.

Mueller MS, Sidharta PN, Voors-Pette C, Darpo B, Xue H, Dingemanse J. Mueller MS, et al. Among authors: darpo b. Orphanet J Rare Dis. 2020 Oct 27;15(1):303. doi: 10.1186/s13023-020-01582-7. Orphanet J Rare Dis. 2020. PMID: 33109218 Free PMC article. Clinical Trial.

8

A Phase 1 Clinical Study Evaluating the Effects of Cenobamate on the QT Interval.

Darpo B, Sager PT, Xue H, Kamin M. Darpo B, et al. Clin Pharmacol Drug Dev. 2022 Apr;11(4):523-534. doi: 10.1002/cpdd.1077. Epub 2022 Feb 19. Clin Pharmacol Drug Dev. 2022. PMID: 35182037 Clinical Trial.

9

Combination of olanzapine and samidorphan has no clinically relevant effects on ECG parameters, including the QTc interval: Results from a phase 1 QT/QTc study.

Sun L, Yagoda S, Xue H, Brown R, Nangia N, McDonnell D, Rege B, von Moltke L, Darpo B. Sun L, et al. Among authors: darpo b. Prog Neuropsychopharmacol Biol Psychiatry. 2020 Jun 8;100:109881. doi: 10.1016/j.pnpbp.2020.109881. Epub 2020 Jan 28. Prog Neuropsychopharmacol Biol Psychiatry. 2020. PMID: 32004636 Free article. Clinical Trial.

10

Safety, Pharmacokinetics, and Pharmacodynamics of Trazpiroben (TAK-906), a Novel Selective D₂ /D₃ Receptor Antagonist: A Phase 1 Randomized, Placebo-Controlled Single- and Multiple-Dose Escalation Study in Healthy Participants.

Whiting RL, Darpo B, Chen C, Fletcher M, Combs D, Xue H, Stoltz RR. Whiting RL, et al. Among authors: darpo b. Clin Pharmacol Drug Dev. 2021 Aug;10(8):927-939. doi: 10.1002/cpdd.906. Epub 2021 Jan 18. Clin Pharmacol Drug Dev. 2021. PMID: 33462988 Free PMC article. Clinical Trial.

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