Ou YC - Search Results

1

No QTc Prolongation With Zanubrutinib: Results of Concentration-QTc Analysis From a Thorough QT Study in Healthy Subjects.

Mu S, Darpo B, Tang Z, Novotny W, Tawashi M, Xue H, Willett M, Lin L, Sahasranaman S, Ou YC. Mu S, et al. Among authors: ou yc. Clin Transl Sci. 2020 Sep;13(5):923-931. doi: 10.1111/cts.12779. Epub 2020 Apr 8. Clin Transl Sci. 2020. PMID: 32144955 Free PMC article. Clinical Trial.

2

Effect of rifampin and itraconazole on the pharmacokinetics of zanubrutinib (a Bruton's tyrosine kinase inhibitor) in Asian and non-Asian healthy subjects.

Mu S, Tang Z, Novotny W, Tawashi M, Li TK, Ou Y, Sahasranaman S. Mu S, et al. Cancer Chemother Pharmacol. 2020 Feb;85(2):391-399. doi: 10.1007/s00280-019-04015-w. Epub 2019 Dec 26. Cancer Chemother Pharmacol. 2020. PMID: 31875923 Free PMC article.

3

A phase 1, open-label, single-dose study of the pharmacokinetics of zanubrutinib in subjects with varying degrees of hepatic impairment.

Ou YC, Preston RA, Marbury TC, Tang Z, Novotny W, Tawashi M, Li TK, Sahasranaman S. Ou YC, et al. Leuk Lymphoma. 2020 Jun;61(6):1355-1363. doi: 10.1080/10428194.2020.1719097. Epub 2020 Feb 7. Leuk Lymphoma. 2020. PMID: 32031037 Clinical Trial.

4

Population Pharmacokinetic Analysis of the BTK Inhibitor Zanubrutinib in Healthy Volunteers and Patients With B-Cell Malignancies.

Ou YC, Liu L, Tariq B, Wang K, Jindal A, Tang Z, Gao Y, Sahasranaman S. Ou YC, et al. Clin Transl Sci. 2021 Mar;14(2):764-772. doi: 10.1111/cts.12948. Epub 2021 Jan 25. Clin Transl Sci. 2021. PMID: 33306268 Free PMC article.

5

Evaluation of drug interaction potential of zanubrutinib with cocktail probes representative of CYP3A4, CYP2C9, CYP2C19, P-gp and BCRP.

Ou YC, Tang Z, Novotny W, Tawashi M, Li TK, Coleman HA, Sahasranaman S. Ou YC, et al. Br J Clin Pharmacol. 2021 Jul;87(7):2926-2936. doi: 10.1111/bcp.14707. Epub 2021 Jan 14. Br J Clin Pharmacol. 2021. PMID: 33336408 Free PMC article.

6

Comprehensive PBPK model to predict drug interaction potential of Zanubrutinib as a victim or perpetrator.

Wang K, Yao X, Zhang M, Liu D, Gao Y, Sahasranaman S, Ou YC. Wang K, et al. Among authors: ou yc. CPT Pharmacometrics Syst Pharmacol. 2021 May;10(5):441-454. doi: 10.1002/psp4.12605. Epub 2021 May 2. CPT Pharmacometrics Syst Pharmacol. 2021. PMID: 33687157 Free PMC article.

7

Rationale for once-daily or twice-daily dosing of zanubrutinib in patients with mantle cell lymphoma.

Ou YC, Tang Z, Novotny W, Cohen A, Wang K, Liu L, Gao Y, Sahasranaman S. Ou YC, et al. Leuk Lymphoma. 2021 Nov;62(11):2612-2624. doi: 10.1080/10428194.2021.1929961. Epub 2021 Jun 23. Leuk Lymphoma. 2021. PMID: 34159878 Clinical Trial.

8

Clinical pharmacology and PK/PD translation of the second-generation Bruton's tyrosine kinase inhibitor, zanubrutinib.

Tam CS, Ou YC, Trotman J, Opat S. Tam CS, et al. Among authors: ou yc. Expert Rev Clin Pharmacol. 2021 Nov;14(11):1329-1344. doi: 10.1080/17512433.2021.1978288. Epub 2021 Sep 20. Expert Rev Clin Pharmacol. 2021. PMID: 34491123 Review.

9

In vitro investigations into the roles of CYP450 enzymes and drug transporters in the drug interactions of zanubrutinib, a covalent Bruton's tyrosine kinase inhibitor.

Zhang H, Ou YC, Su D, Wang F, Wang L, Sahasranaman S, Tang Z. Zhang H, et al. Among authors: ou yc. Pharmacol Res Perspect. 2021 Dec;9(6):e00870. doi: 10.1002/prp2.870. Pharmacol Res Perspect. 2021. PMID: 34664792 Free PMC article.

10

A two-part, single-arm, multicentre, phase I study of zanubrutinib, a selective Bruton tyrosine kinase inhibitor, in Chinese patients with relapsed/refractory B-cell malignancies.

Song Y, Sun M, Qi J, Xu W, Zhou J, Li D, Li J, Qiu L, Du C, Guo H, Huang J, Tang Z, Ou Y, Wu B, Yu Y, Zhu J. Song Y, et al. Br J Haematol. 2022 Jul;198(1):62-72. doi: 10.1111/bjh.18162. Epub 2022 Apr 5. Br J Haematol. 2022. PMID: 35383885 Free PMC article. Clinical Trial.

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