Keegan PM - Search Results

1

Sickle Cell Anemia Mediates Carotid Artery Expansive Remodeling That Can Be Prevented by Inhibition of JNK (c-Jun N-Terminal Kinase).

Song H, Keegan PM, Anbazhakan S, Rivera CP, Feng Y, Omojola VO, Clark AA, Cai S, Selma J, Gleason RL Jr, Botchwey EA, Huo Y, Tan W, Platt MO. Song H, et al. Among authors: keegan pm. Arterioscler Thromb Vasc Biol. 2020 May;40(5):1220-1230. doi: 10.1161/ATVBAHA.120.314045. Epub 2020 Mar 12. Arterioscler Thromb Vasc Biol. 2020. PMID: 32160775 Free PMC article.

2

Sickle cell disease activates peripheral blood mononuclear cells to induce cathepsins k and v activity in endothelial cells.

Keegan PM, Surapaneni S, Platt MO. Keegan PM, et al. Anemia. 2012;2012:201781. doi: 10.1155/2012/201781. Epub 2012 Apr 9. Anemia. 2012. PMID: 22550569 Free PMC article.

3

Tumor necrosis factor alpha stimulates cathepsin K and V activity via juxtacrine monocyte-endothelial cell signaling and JNK activation.

Keegan PM, Wilder CL, Platt MO. Keegan PM, et al. Mol Cell Biochem. 2012 Aug;367(1-2):65-72. doi: 10.1007/s11010-012-1320-0. Epub 2012 May 5. Mol Cell Biochem. 2012. PMID: 22562303 Free PMC article.

4

Acid sphingomyelinase is activated in sickle cell erythrocytes and contributes to inflammatory microparticle generation in SCD.

Awojoodu AO, Keegan PM, Lane AR, Zhang Y, Lynch KR, Platt MO, Botchwey EA. Awojoodu AO, et al. Among authors: keegan pm. Blood. 2014 Sep 18;124(12):1941-50. doi: 10.1182/blood-2014-01-543652. Epub 2014 Jul 29. Blood. 2014. PMID: 25075126 Free PMC article.

5

Experimental and imaging techniques for examining fibrin clot structures in normal and diseased states.

Fan NK, Keegan PM, Platt MO, Averett RD. Fan NK, et al. Among authors: keegan pm. J Vis Exp. 2015 Apr 1;(98):e52019. doi: 10.3791/52019. J Vis Exp. 2015. PMID: 25867016 Free PMC article.

6

Manipulating substrate and pH in zymography protocols selectively distinguishes cathepsins K, L, S, and V activity in cells and tissues.

Wilder CL, Park KY, Keegan PM, Platt MO. Wilder CL, et al. Among authors: keegan pm. Arch Biochem Biophys. 2011 Dec 1;516(1):52-7. doi: 10.1016/j.abb.2011.09.009. Epub 2011 Sep 29. Arch Biochem Biophys. 2011. PMID: 21982919 Free PMC article.

7

Biomechanical and biochemical regulation of cathepsin K expression in endothelial cells converge at AP-1 and NF-κB.

Keegan PM, Anbazhakan S, Kang B, Pace BS, Platt MO. Keegan PM, et al. Biol Chem. 2016 May;397(5):459-68. doi: 10.1515/hsz-2015-0244. Biol Chem. 2016. PMID: 26760306 Free PMC article.

8

Low-Cost Method to Monitor Patient Adherence to HIV Antiretroviral Therapy Using Multiplex Cathepsin Zymography.

Platt MO, Evans D, Keegan PM, McNamara L, Parker IK, Roberts LM, Caulk AW, Gleason RL Jr, Seifu D, Amogne W, Penny C. Platt MO, et al. Among authors: keegan pm. Mol Biotechnol. 2016 Jan;58(1):56-64. doi: 10.1007/s12033-015-9903-0. Mol Biotechnol. 2016. PMID: 26589706 Free PMC article.

9

Detection of femtomole quantities of mature cathepsin K with zymography.

Li WA, Barry ZT, Cohen JD, Wilder CL, Deeds RJ, Keegan PM, Platt MO. Li WA, et al. Among authors: keegan pm. Anal Biochem. 2010 Jun 1;401(1):91-8. doi: 10.1016/j.ab.2010.02.035. Epub 2010 Mar 3. Anal Biochem. 2010. PMID: 20206119

10

A high-throughput microfluidic bilayer co-culture platform to study endothelial-pericyte interactions.

Rogers MT, Gard AL, Gaibler R, Mulhern TJ, Strelnikov R, Azizgolshani H, Cain BP, Isenberg BC, Haroutunian NJ, Raustad NE, Keegan PM, Lech MP, Tomlinson L, Borenstein JT, Charest JL, Williams C. Rogers MT, et al. Among authors: keegan pm. Sci Rep. 2021 Jun 9;11(1):12225. doi: 10.1038/s41598-021-90833-z. Sci Rep. 2021. PMID: 34108507 Free PMC article.

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