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BRAINSTORM: A Multi-Institutional Phase 1/2 Study of RRx-001 in Combination With Whole Brain Radiation Therapy for Patients With Brain Metastases.
Kim MM, Parmar HA, Schipper M, Devasia T, Aryal MP, Kesari S, O'Day S, Morikawa A, Spratt DE, Junck L, Mammoser A, Hayman JA, Lawrence TS, Tsien CI, Aiken R, Goyal S, Abrouk N, Trimble M, Cao Y, Lao CD. Kim MM, et al. Among authors: abrouk n. Int J Radiat Oncol Biol Phys. 2020 Jul 1;107(3):478-486. doi: 10.1016/j.ijrobp.2020.02.639. Epub 2020 Mar 10. Int J Radiat Oncol Biol Phys. 2020. PMID: 32169409 Free article. Clinical Trial.
In small cell lung cancer patients treated with RRx-001, a downregulator of CD47, decreased expression of PD-L1 on circulating tumor cells significantly correlates with clinical benefit.
Tomita Y, Oronsky B, Abrouk N, Cabrales P, Reid TR, Lee MJ, Yuno A, Baker J, Lee S, Trepel JB. Tomita Y, et al. Among authors: abrouk n. Transl Lung Cancer Res. 2021 Jan;10(1):274-278. doi: 10.21037/tlcr-20-359. Transl Lung Cancer Res. 2021. PMID: 33569311 Free PMC article.
A 2022 Update on Extensive Stage Small-Cell Lung Cancer (SCLC).
Oronsky B, Abrouk N, Caroen S, Lybeck M, Guo X, Wang X, Yu Z, Reid T. Oronsky B, et al. Among authors: abrouk n. J Cancer. 2022 Jul 18;13(9):2945-2953. doi: 10.7150/jca.75622. eCollection 2022. J Cancer. 2022. PMID: 35912017 Free PMC article. Review.
Discovery of RRx-001, a Myc and CD47 Downregulating Small Molecule with Tumor Targeted Cytotoxicity and Healthy Tissue Cytoprotective Properties in Clinical Development.
Oronsky B, Guo X, Wang X, Cabrales P, Sher D, Cannizzo L, Wardle B, Abrouk N, Lybeck M, Caroen S, Oronsky A, Reid TR. Oronsky B, et al. Among authors: abrouk n. J Med Chem. 2021 Jun 10;64(11):7261-7271. doi: 10.1021/acs.jmedchem.1c00599. Epub 2021 May 27. J Med Chem. 2021. PMID: 34043360 Free article.
Lost at SCLC: a review of potential platinum sensitizers.
Oronsky B, Abrouk N, Mao L, Shen Y, Wang X, Zhao L, Caroen S, Reid T. Oronsky B, et al. Among authors: abrouk n. Cancer Metastasis Rev. 2024 Dec;43(4):1573-1578. doi: 10.1007/s10555-024-10207-5. Epub 2024 Aug 23. Cancer Metastasis Rev. 2024. PMID: 39177894 Free PMC article. Review.
BETA prime: a first-in-man phase 1 study of AdAPT-001, an armed oncolytic adenovirus for solid tumors.
Conley AP, Roland CL, Bessudo A, Gastman BR, Villaflor VM, Larson C, Reid TR, Caroen S, Oronsky B, Stirn M, Williams J, Burbano E, Coyle A, Barve MA, Wagle N, Abrouk N, Kesari S. Conley AP, et al. Among authors: abrouk n. Cancer Gene Ther. 2024 Apr;31(4):517-526. doi: 10.1038/s41417-023-00720-0. Epub 2023 Dec 25. Cancer Gene Ther. 2024. PMID: 38146006 Free PMC article. Clinical Trial.
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