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Local endothelial DNA repair deficiency causes aging-resembling endothelial-specific dysfunction.
Bautista-Niño PK, Portilla-Fernandez E, Rubio-Beltrán E, van der Linden JJ, de Vries R, van Veghel R, de Boer M, Durik M, Ridwan Y, Brandt R, Essers J, Menzies RI, Thomas R, de Bruin A, Duncker DJ, van Beusekom HMM, Ghanbari M, Hoeijmakers JHJ, Sedlacek R, Touyz RM, Montezano AC, van der Pluijm I, Danser AHJ, Haanes KA, Roks AJM. Bautista-Niño PK, et al. Clin Sci (Lond). 2020 Apr 17;134(7):727-746. doi: 10.1042/CS20190124. Clin Sci (Lond). 2020. PMID: 32202295 Free article.
DNA Damage: A Main Determinant of Vascular Aging.
Bautista-Niño PK, Portilla-Fernandez E, Vaughan DE, Danser AH, Roks AJ. Bautista-Niño PK, et al. Int J Mol Sci. 2016 May 18;17(5):748. doi: 10.3390/ijms17050748. Int J Mol Sci. 2016. PMID: 27213333 Free PMC article. Review.
Unlike dietary restriction, rapamycin fails to extend lifespan and reduce transcription stress in progeroid DNA repair-deficient mice.
Birkisdóttir MB, Jaarsma D, Brandt RMC, Barnhoorn S, van Vliet N, Imholz S, van Oostrom CT, Nagarajah B, Portilla Fernández E, Roks AJM, Elgersma Y, van Steeg H, Ferreira JA, Pennings JLA, Hoeijmakers JHJ, Vermeij WP, Dollé MET. Birkisdóttir MB, et al. Among authors: portilla fernandez e. Aging Cell. 2021 Feb;20(2):e13302. doi: 10.1111/acel.13302. Epub 2021 Jan 23. Aging Cell. 2021. PMID: 33484480 Free PMC article.
Genetic and clinical determinants of abdominal aortic diameter: genome-wide association studies, exome array data and Mendelian randomization study.
Portilla-Fernandez E, Klarin D, Hwang SJ, Biggs ML, Bis JC, Weiss S, Rospleszcz S, Natarajan P, Hoffmann U, Rogers IS, Truong QA, Völker U, Dörr M, Bülow R, Criqui MH, Allison M, Ganesh SK, Yao J, Waldenberger M, Bamberg F, Rice KM, Essers J, Kapteijn DMC, van der Laan SW, de Knegt RJ, Ghanbari M, Felix JF, Ikram MA, Kavousi M, Uitterlinden AG, Roks AJM, Danser AHJ, Tsao PS, Damrauer SM, Guo X, Rotter JI, Psaty BM, Kathiresan S, Völzke H, Peters A, Johnson C, Strauch K, Meitinger T, O'Donnell CJ, Dehghan A; VA Million Veteran Program. Portilla-Fernandez E, et al. Hum Mol Genet. 2022 Oct 10;31(20):3566-3579. doi: 10.1093/hmg/ddac051. Hum Mol Genet. 2022. PMID: 35234888 Free PMC article.
Meta-analysis of epigenome-wide association studies of carotid intima-media thickness.
Portilla-Fernández E, Hwang SJ, Wilson R, Maddock J, Hill WD, Teumer A, Mishra PP, Brody JA, Joehanes R, Ligthart S, Ghanbari M, Kavousi M, Roks AJM, Danser AHJ, Levy D, Peters A, Ghasemi S, Schminke U, Dörr M, Grabe HJ, Lehtimäki T, Kähönen M, Hurme MA, Bartz TM, Sotoodehnia N, Bis JC, Thiery J, Koenig W, Ong KK, Bell JT, Meisinger C, Wardlaw JM, Starr JM, Seissler J, Then C, Rathmann W, Ikram MA, Psaty BM, Raitakari OT, Völzke H, Deary IJ, Wong A, Waldenberger M, O'Donnell CJ, Dehghan A. Portilla-Fernández E, et al. Eur J Epidemiol. 2021 Nov;36(11):1143-1155. doi: 10.1007/s10654-021-00759-z. Epub 2021 Jun 6. Eur J Epidemiol. 2021. PMID: 34091768 Free PMC article.
Phytoestrogen supplementation and body composition in postmenopausal women: A systematic review and meta-analysis of randomized controlled trials.
Glisic M, Kastrati N, Musa J, Milic J, Asllanaj E, Portilla Fernandez E, Nano J, Ochoa Rosales C, Amiri M, Kraja B, Bano A, Bramer WM, Roks AJM, Danser AHJ, Franco OH, Muka T. Glisic M, et al. Maturitas. 2018 Sep;115:74-83. doi: 10.1016/j.maturitas.2018.06.012. Epub 2018 Jun 22. Maturitas. 2018. PMID: 30049351 Free article. Review.
20 results