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Two distinct ubiquitin-binding motifs in A20 mediate its anti-inflammatory and cell-protective activities.
Martens A, Priem D, Hoste E, Vetters J, Rennen S, Catrysse L, Voet S, Deelen L, Sze M, Vikkula H, Slowicka K, Hochepied T, Iliaki K, Wullaert A, Janssens S, Lamkanfi M, Beyaert R, Armaka M, Bertrand MJM, van Loo G. Martens A, et al. Among authors: lamkanfi m. Nat Immunol. 2020 Apr;21(4):381-387. doi: 10.1038/s41590-020-0621-9. Epub 2020 Mar 16. Nat Immunol. 2020. PMID: 32205881
Interaction patches of procaspase-1 caspase recruitment domains (CARDs) are differently involved in procaspase-1 activation and receptor-interacting protein 2 (RIP2)-dependent nuclear factor κB signaling.
Kersse K, Lamkanfi M, Bertrand MJM, Vanden Berghe T, Vandenabeele P. Kersse K, et al. Among authors: lamkanfi m. J Biol Chem. 2011 Oct 14;286(41):35874-35882. doi: 10.1074/jbc.M111.242321. Epub 2011 Aug 23. J Biol Chem. 2011. PMID: 21862576 Free PMC article.
Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis.
Vande Walle L, Van Opdenbosch N, Jacques P, Fossoul A, Verheugen E, Vogel P, Beyaert R, Elewaut D, Kanneganti TD, van Loo G, Lamkanfi M. Vande Walle L, et al. Among authors: lamkanfi m. Nature. 2014 Aug 7;512(7512):69-73. doi: 10.1038/nature13322. Epub 2014 Jun 29. Nature. 2014. PMID: 25043000 Free PMC article.
The NEK-sus of the NLRP3 inflammasome.
Van Hauwermeiren F, Lamkanfi M. Van Hauwermeiren F, et al. Among authors: lamkanfi m. Nat Immunol. 2016 Mar;17(3):223-4. doi: 10.1038/ni.3391. Nat Immunol. 2016. PMID: 26882252 No abstract available.
General Strategies in Inflammasome Biology.
Dubois H, Wullaert A, Lamkanfi M. Dubois H, et al. Among authors: lamkanfi m. Curr Top Microbiol Immunol. 2016;397:1-22. doi: 10.1007/978-3-319-41171-2_1. Curr Top Microbiol Immunol. 2016. PMID: 27460802 Review.
NLRP2 controls age-associated maternal fertility.
Kuchmiy AA, D'Hont J, Hochepied T, Lamkanfi M. Kuchmiy AA, et al. Among authors: lamkanfi m. J Exp Med. 2016 Dec 12;213(13):2851-2860. doi: 10.1084/jem.20160900. Epub 2016 Nov 23. J Exp Med. 2016. PMID: 27881734 Free PMC article.
Nlrp6- and ASC-Dependent Inflammasomes Do Not Shape the Commensal Gut Microbiota Composition.
Mamantopoulos M, Ronchi F, Van Hauwermeiren F, Vieira-Silva S, Yilmaz B, Martens L, Saeys Y, Drexler SK, Yazdi AS, Raes J, Lamkanfi M, McCoy KD, Wullaert A. Mamantopoulos M, et al. Among authors: lamkanfi m. Immunity. 2017 Aug 15;47(2):339-348.e4. doi: 10.1016/j.immuni.2017.07.011. Epub 2017 Aug 8. Immunity. 2017. PMID: 28801232 Free article.
Caspase-1 Engagement and TLR-Induced c-FLIP Expression Suppress ASC/Caspase-8-Dependent Apoptosis by Inflammasome Sensors NLRP1b and NLRC4.
Van Opdenbosch N, Van Gorp H, Verdonckt M, Saavedra PHV, de Vasconcelos NM, Gonçalves A, Vande Walle L, Demon D, Matusiak M, Van Hauwermeiren F, D'Hont J, Hochepied T, Krautwald S, Kanneganti TD, Lamkanfi M. Van Opdenbosch N, et al. Among authors: lamkanfi m. Cell Rep. 2017 Dec 19;21(12):3427-3444. doi: 10.1016/j.celrep.2017.11.088. Cell Rep. 2017. PMID: 29262324 Free PMC article.
161 results